In this study, we investigated the feasibility of using 3.5-Fr intravascular ultrasound (IVUS) catheters for minimally-invasive, image-guided hyperthermia treatment of tumors in the brain. Feasibility was demonstrated by: (1) retro-fitting a commercial 3.5-Fr IVUS catheter with a 5 x 0.5 x 0.22 mm PZT-4 transducer for 9-MHz imaging and (2) testing an identical transducer for therapy potential with 3.3-MHz continuous-wave excitation. The imaging transducer was compared with a 9-Fr, 9-MHz ICE catheter when visualizing the post-mortem ovine brain and was also used to attempt vascular access to an in vivo porcine brain. A net average electrical power input of 700 mW was applied to the therapy transducer, producing a temperature rise of +13.5 degrees C at a depth of 1.5 mm in live brain tumor tissue in the mouse model. These results suggest that it may be feasible to combine the imaging and therapeutic capabilities into a single device as a clinically-viable instrument.
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机译：在这项研究中，我们调查了使用3.5-Fr血管内超声（IVUS）导管对脑部肿瘤进行微创，图像引导热疗的可行性。通过以下方式证明了可行性：（1）用5 x 0.5 x 0.22 mm PZT-4换能器对商用3.5-Fr IVUS导管进行改装，以进行9MHz成像;（2）测试相同的换能器在3.3MHz的治疗潜力连续波激发。可视化尸体后的绵羊大脑时，将成像换能器与9-Fr，9-MHz ICE导管进行了比较，还用于尝试通过血管进入体内猪脑。将700 mW的净平均电功率输入施加到治疗换能器，在小鼠模型中的活脑肿瘤组织中，在1.5毫米深度处产生+13.5摄氏度的温度升高。这些结果表明，将成像和治疗功能结合到一个可作为临床可行仪器的设备中可能是可行的。
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