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首页> 外文期刊>Ultrasound in Medicine and Biology >Three-dimensional ultrasonography can detect the modulation of kidney volume in two-kidney, one-clip hypertensive rats.
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Three-dimensional ultrasonography can detect the modulation of kidney volume in two-kidney, one-clip hypertensive rats.

机译：三维超声检查可以检测二肾一夹高血压大鼠的肾脏体积调节。

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摘要

As volume changes are a typical finding in the two-kidney, one-clip hypertensive rat model (2K1C), it is of interest to investigate within what time frame these volume changes occur and their relation to hypertension. Kidney volume changes in Wistar rats were measured by three-dimensional (3D) ultrasonography (USG). Clipped induced stenosis was applied to the left renal artery in 11-wk-old animals (n = 8), using age-matched nonclipped rats as controls (n = 7). Ultrasonographic recordings were made before clipping and, thereafter, weekly with corresponding systolic blood pressure and body weight measurements. The nonclipped kidney showed increased volume at week 2, 5 and 7. Three wk after clipping, clipped kidneys were smaller than the nonclipped kidneys (0.47 +/- 0.11 mL versus 1.28 +/- 0.07 mL). No difference was found between the left and right kidney in the control group at any week. Blood pressure was significantly higher in the 2K1C hypertensive group 4 weeks after clipping (201 +/- 16 versus 139 +/- 4 mm Hg) with stable blood pressure thereafter. Three-dimensional USG showed that clipping caused a decrease in kidney volume from week 3 in the clipped kidney and a volume increase in the nonclipped kidney at week 2. A significant increase in blood pressure appeared after week 4.
机译：由于体积变化是两肾一夹高血压大鼠模型（2K1C）的典型发现，因此研究这些体积变化在什么时间范围内发生及其与高血压的关系是很有意义的。通过三维（3D）超声检查（USG）测量Wistar大鼠的肾脏体积变化。使用年龄匹配的非夹闭大鼠作为对照（n = 7），将截留诱导的狭窄应用于11周龄动物（n = 8）的左肾动脉。在修剪之前和之后每周进行超声记录，并进行相应的收缩压和体重测量。未修剪的肾脏在第2、5和7周显示体积增加。修剪后3周，修剪的肾脏比未修剪的肾脏小（0.47 +/- 0.11 mL对1.28 +/- 0.07 mL）。在任何星期，对照组的左肾和右肾之间都没有发现差异。截断后4周，2K1C高血压组的血压明显升高（201 +/- 16对139 +/- 4 mm Hg），此后血压稳定。三维USG显示，从第3周开始，修剪会导致修剪后的肾脏中肾脏体积减少，而在第2周时未修剪的肾脏中肾脏体积会增加。第4周后，血压显着升高。

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