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首页> 外文期刊>Ultrasound in Medicine and Biology >High frequency ultrasound imaging detects cardiac dyssynchrony in noninfarcted regions of the murine left ventricle late after reperfused myocardial infarction.
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High frequency ultrasound imaging detects cardiac dyssynchrony in noninfarcted regions of the murine left ventricle late after reperfused myocardial infarction.

机译：高频超声成像可在再灌注心肌梗塞后晚在鼠左心室非梗塞区域检测到心脏不同步。

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摘要

Cardiac dyssynchrony in the left ventricles of murine hearts late (> or =28 d) after reperfused myocardial infarction (post-MI) was assessed using high frequency 30 MHz B-mode ultrasound imaging. Nine post-MI and six normal C57Bl/6 mice were studied in both short- and long-axis views. Regional time to peak displacement (T(peak_d)) and time to peak strain (T(peak_s)) were calculated in 36 sectors along the myocardial circumference; then their standard deviations (SD_T(peak_d) and SD_T(peak_s)) were computed among noninfarcted myocardial regions for each mouse and were compared between the normal and post-MI mouse groups with Student's t-test. The comparison revealed that SD_T(peak_d) and SD_T(peak_s) were significantly larger in the post-MI hearts than in the normal hearts. The displacement uniformity ratio was determined to be 0.97 +/- 0.01 and 0.85 +/- 0.07 for radial and circumferential displacements in the normal hearts, respectively; and 0.59 +/- 0.17 and 0.64 +/- 0.24 in the post-MI hearts. In conclusion, this high resolution ultrasound image tracking method provides for the detection of cardiac dyssynchrony in the noninfarcted regions in the murine left ventricles late after MI by identifying the temporal and spatial disparity of regional myocardial contraction.
机译：使用高频30 MHz B型超声成像评估了再灌注心肌梗塞（MI后）后（> 28 d或= 28 d）小鼠心脏左心室的心律失常。在短轴和长轴视图中研究了九只MI后的小鼠和六只正常的C57Bl / 6小鼠。计算沿心肌周长的36个扇形区的峰位移时间（T（peak_d））和峰应变时间（T（peak_s））。然后计算每只小鼠在非梗死心肌区域之间的标准偏差（SD_T（peak_d）和SD_T（peak_s）），并通过Student t检验比较正常和MI后的小鼠组。比较显示，MI后心脏的SD_T（peak_d）和SD_T（peak_s）显着大于正常心脏。对于正常心脏中的径向和圆周位移，位移均匀度比分别确定为0.97 +/- 0.01和0.85 +/- 0.07。在心梗后心脏中为0.59 +/- 0.17和0.64 +/- 0.24。总之，这种高分辨率超声图像跟踪方法可通过识别局部心肌收缩的时空差异，检测出MI后鼠左心室非梗塞区域的心脏不同步。

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