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首页> 外文期刊>Chemistry: A European journal >Selective Formation of 2-Imidazolines and 2-Substituted Oxazoles by Using a Three-Component Reaction
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Selective Formation of 2-Imidazolines and 2-Substituted Oxazoles by Using a Three-Component Reaction

机译：通过三组分反应选择性形成2-咪唑啉和2-取代的恶唑

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摘要

Selective formation of 2H-2-imidazolines and 2-substituted oxazoles by using a multicomponent reaction of amines, either aldehydes or ketones, and a-acidic isocyano amides or esters is described. By selecting the appropriate solvent, AgI or CuI catalyst, or by employing a weak Bronsted acid, the product formation can be fully controlled and directed quantitatively to the desired heterocyclic scaffold. The described experimental procedures not only significantly increase the scope of compatible inputs for this complexitygenerating three-component reaction, but also allow for considerable chemical diversity: At least four diversity points in two distinct scaffolds can be exploited in this way.
机译：描述了通过使用胺，醛或酮与α-酸性异氰基酰胺或酯的多组分反应来选择性形成2H-2-咪唑啉和2-取代的恶唑。通过选择合适的溶剂，AgI或CuI催化剂，或通过使用弱布朗斯台德酸，可以完全控制产物的形成并将其定量地导向所需的杂环骨架。所描述的实验程序不仅显着增加了该复杂性生成三组分反应的相容性输入范围，而且还允许相当大的化学多样性：以这种方式可以利用两个不同支架中的至少四个多样性点。

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