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首页> 外文期刊>Chemistry: A European journal >Improving the Trapping of Superoxide Radical with a b-Cyclodextrin– 5-Diethoxyphosphoryl-5-methyl-1-pyrroline-N-oxide (DEPMPO) Conjugate
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Improving the Trapping of Superoxide Radical with a b-Cyclodextrin– 5-Diethoxyphosphoryl-5-methyl-1-pyrroline-N-oxide (DEPMPO) Conjugate

机译：用b-环糊精–5-二乙氧基磷酰基-5-甲基-1-吡咯啉-N-氧化物（DEPMPO）结合物改善超氧化物自由基的捕集

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摘要

During the last decade, the detection of superoxide radical in biological systems continued to receive increasing attention. The superoxide radical is positioned upstream in many free radical cascades leading to reactive oxygen species (ROS). These species are assumed to act as mediators in various physiological and pathological processes, such as signal transduction, aging, inflammatory- and age-related diseases.[1–3] The search for reliable tools to study ROS in biological systems is important not only for unraveling their complex contributions but also for the development of diagnostic and therapeutic applications. In recent years, hydroethidine derivatives and other fluorescent probes have been developed successfully as ROS probes.[4–6] However, the complexity of the dye chemistry in biological systems could lead potentially to misinterpretations concerning the ROS implication,[7, 8] and so there is a need to develop complementary techniques.
机译：在过去的十年中，生物系统中超氧自由基的检测继续受到越来越多的关注。超氧化物自由基位于许多自由基级联反应的上游，从而导致活性氧（ROS）。假定这些物种在各种生理和病理过程中充当介体，例如信号转导，衰老，与年龄有关的炎症和疾病。[1-3]寻找可靠的工具来研究生物系统中的ROS不仅重要阐明其复杂的作用，还用于诊断和治疗应用程序的开发。近年来，已成功开发了氢乙啶衍生物和其他荧光探针作为ROS探针。[4-6]但是，生物系统中染料化学的复杂性可能导致对ROS含义的误解[7、8]和因此需要开发补充技术。

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