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首页> 外文期刊>Chemistry: A European journal >Boron-based dipolar multicomponent reactions: Simple generation of substituted aziridines, oxazolidines and pyrrolidines
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Boron-based dipolar multicomponent reactions: Simple generation of substituted aziridines, oxazolidines and pyrrolidines

机译：基于硼的偶极多组分反应：取代氮丙啶，恶唑烷和吡咯烷的简单生成

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摘要

New multicomponent reactions of aldehydes, isocyanides, trialkylboron reagents and dipolarophiles have been developed as an efficient route to diverse scaffolds, including aziridines, oxazolidines and poly-substituted pyrrolidines. This chemistry, inspired by a report by Hesse in 1965, is simple and involves mild conditions. Computational studies provide a basis to investigate the stereochemical features observed in the formation of oxazolidines and fourcomponent adducts, and permit identification of potential factors that might influence the outcome of the multicomponent reaction. Thus, a rational screening of all the components and reaction parameters is made to examine the manifold mechanistic pathways and establish the practical limits for standard applications. Finally, intramolecular and solid-supported versions of these reactions bring new synthetic possibilities and practical protocols. Overall, the results describe a new family of multicomponent reactions valuable not only for organic reactivity, but also for combinatorial chemistry and drug discovery.
机译：醛，异氰酸酯，三烷基硼试剂和偶极亲和剂的新的多组分反应已被开发为通往包括氮丙啶，恶唑烷和多取代的吡咯烷的多种支架的有效途径。这种化学反应受黑森（Hesse）1965年的一份报告的启发，很简单，涉及的条件温和。计算研究提供了基础，以研究在恶唑烷和四组分加合物形成中观察到的立体化学特征，并允许鉴定可能影响多组分反应结果的潜在因素。因此，对所有组分和反应参数进行了合理的筛选，以检查多种机械途径并确定标准应用的实际限制。最后，这些反应的分子内和固相支持形式带来了新的合成可能性和实用方案。总的来说，结果描述了一个新的多组分反应家族，不仅对于有机反应性，而且对于组合化学和药物发现都很有价值。

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