Total synthesis and antibiotic activity of dehydrohomoplatencin

Waalboer D.C.J.; Leenders S.H.A.M.; Schülin-Casonato T.; Van Delft F.L.; Rutjes F.P.J.T.

首页> 外文期刊>Chemistry: A European journal >Total synthesis and antibiotic activity of dehydrohomoplatencin

【24h】

Total synthesis and antibiotic activity of dehydrohomoplatencin

机译：脱氢高铂素的总合成及抗菌活性

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

Expanding antibiotics: A concise synthesis of dehydrohomoplatencin a novel derivative of the naturally occurring antibiotic platencin has been realized (see scheme). Notably the synthesis of the ketolide portion of the molecule was achieved in only two exceedingly simple steps. Compared to platencin dehydrohomoplatencin showed virtually equipotent antibacterial activity against Gram-positive bacteria and may serve as a novel lead structure for the development of new antibiotics.

机译：扩展抗生素：已经实现了简朴的脱氢高纯素的合成，这是天然存在的抗生素高纯素的新型衍生物（参见方案）。值得注意的是，分子的酮内酯部分的合成仅通过两个极其简单的步骤即可完成。与Platencin相比，dehydrohomoplatencin对革兰氏阳性细菌几乎具有同等的抗菌活性，并且可以作为开发新抗生素的新型先导结构。

著录项

来源
《Chemistry: A European journal》 |2010年第37期|共4页
作者
Waalboer D.C.J.; Leenders S.H.A.M.; Schülin-Casonato T.; Van Delft F.L.; Rutjes F.P.J.T.;
展开▼
作者单位

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类应用化学;
关键词
Antibiotics; Medicinal chemistry; Platencin; Prins reaction; Total synthesis;

机译：抗生素;药物化学;铂霉素;Prins反应;全合成;

相似文献

外文文献
中文文献
专利

1. Total synthesis and antibiotic activity of dehydrohomoplatencin [J] . Waalboer D.C.J., Leenders S.H.A.M., Schülin-Casonato T., Chemistry: A European journal . 2010,第37期

机译：脱氢高铂素的总合成及抗菌活性
2. The first total synthesis and solution structure of a polypeptin, PE2, a cyclic lipopeptide with broad spectrum antibiotic activity [J] . Mountford Simon J., Mohanty Biswaranjan, Roberts Kade D., Organic & biomolecular chemistry . 2017,第34期

机译：具有广谱抗生素活性的多肽多肽PE2（一种环状脂肽）的第一个全合成和溶液结构
3. Total Synthesis and Examination of Three Key Analogues of Ramoplanin: A Lipoglycodepsipeptide with Potent Antibiotic Activity [J] . Yosup Rew, Dongwoo Shin, Inkyu Hwang, Journal of the American Chemical Society . 2004,第4期

机译：雷莫拉宁的三个关键类似物的全合成和检验：具有强抗生素活性的脂糖苷肽
4. Lipodepsipeptide antibiotic fusaricidin and its analogues. Total solid-phase and biological activity. [C] . Maciej Stawikowski, Pedrag Cudic American Peptide Symposium . 2009

机译：Lipodepsipeptide抗生素患者及其类似物。总固相和生物活性。
5. Total Synthesis of Cleistrioside/Cleistetroside Analogues, Aminoglycoside Antibiotics and Their Structure Activity Relationship Study. [D] . Shi, Pei. 2015

机译：香菇甙/油香菇苷类似物，氨基糖苷类抗生素的全合成及其结构活性关系的研究。
6. One-Pot Enzymatic Total Synthesis of Presteffimycinone an Early Intermediate of the Anthracycline Antibiotic Steffimycin Biosynthesis [O] . Guojun Wang, Jing Chen, Haining Zhu, -1

机译：一锅酶法全合成Presteffimycinone蒽环类抗生素抗生素Steffimycin生物合成的早期中间体
7. Total Synthesis and Examination of Three Key Analogues of Ramoplanin: A Lipoglycodepsipeptide with Potent Antibiotic Activity [O] . -1

机译：ramoplanin三个键类似物的总合成和检查：一种脂质疏松活性活性活性
8. Drug Development of the Antimalarial Agent Artemisinin: Total Synthesis, AnalogSynthesis, and Structure-Activity Relationship Studies [R] . Avery, M. A. 1990

机译：抗疟药青蒿素的药物开发：全合成，类似合成和结构 - 活性关系研究

Total synthesis and antibiotic activity of dehydrohomoplatencin

摘要

著录项

相似文献

相关主题

期刊订阅