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Drug Development of the Antimalarial Agent Artemisinin: Total Synthesis, AnalogSynthesis, and Structure-Activity Relationship Studies

机译：抗疟药青蒿素的药物开发：全合成，类似合成和结构 - 活性关系研究

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The enantioselective total synthesis of (+)-artemisinin has been optimized andcarried out at multigram scale. An alternate approach to the total synthesis afforded racemic 6, 9-desmethylartemisinin 79 and a related analog 80. A synthetic intermediate from the total synthesis, (+)-acid 32, has been alkylated

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作者
Avery, M. A.;
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年度 1990
页码
总页数 112
原文格式 PDF
正文语种 eng
中图分类工业技术;
关键词
Synthesis; Analog systems; Cyclohexanes; Drugs; Rings;

机译：合成;模拟系统;环己烷;药物;环;

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1. Structure-Activity Relationships of the Antimalarial Agent Artemisinin. 8. Design, Synthesis, and CoMFA Studies toward the Development of Artemisinin-Based Drugs against Leishmaniasis and Malaria [J] . Mitchell A. Avery, Kannoth M. Muraleedharan, Prashant V. Desai, Journal of Medicinal Chemistry . 2003,第20期

机译：抗疟药青蒿素的构效关系。 8.设计，合成和CoMFA研究，以开发基于青蒿素的抗利什曼病和疟疾药物
2. Structure-Activity Relationships of the Antimalarial Agent Artemisinin. 7. Direct Modification of (+)-Artemisinin and In Vivo Antimalarial Screening of New, Potential Preclinical Antimalarial Candidates [J] . Mitchell A. Avery, Maria Alvim-Gaston, Jeffrey A Vroman, Journal of Medicinal Chemistry . 2002,第19期

机译：抗疟药青蒿素的构效关系。 7.（+）-青蒿素的直接修饰和体内新的潜在临床前抗疟候选药物的体内抗疟药物筛选
3. Structure-activity relationships of the antimalarial agent artemisinin. 6. The development of predictive in vitro potency models using CoMFA and HQSAR methodologies. [J] . Avery MitchellA, Alvim-Gaston Maria, Rodrigues CarlosR, Journal of Medicinal Chemistry . 2002,第2期

机译：抗疟药青蒿素的构效关系。 6.使用CoMFA和HQSAR方法开发体外预测性效能模型。
4. Synthesis and Structure-Activity Relationship Study of Cyclic Dipeptide-based Microtubule Depolymerization Agents with a Benzophenone Structure [C] . Makiko Sumikura, Yuri Yamazaki, Tomoko Yoshida Japanese peptide symposium . 2010

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5. Studies on molecular mechanism of action and synthesis of new derivatives of the antimalarial drug artemisinin. [D] . Ho, Wing Yan. 2004

机译：研究抗疟药物青蒿素的分子作用机理和新衍生物的合成。
6. Antimalarial agents against both sexual and asexual parasites stages: structure-activity relationships and biological studies of the Malaria Box compound 1-5-(4-bromo-2-chlorophenyl)furan-2-yl-N-(piperidin-4-yl)methylmethanamine (MMV019918) and analogues [O] . Alessandra Vallone, Sarah D’Alessandro, Simone Brogi, -1

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7. Clotrimazole scaffold as an innovative pharmacophore towards potent antimalarial agents: Design, synthesis, and biological and structure-activity relationship studies [O] . Gemma S, Campiani G, Butini S, 2008

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Drug Development of the Antimalarial Agent Artemisinin: Total Synthesis, AnalogSynthesis, and Structure-Activity Relationship Studies

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