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首页> 外文期刊>Chemistry: A European journal >Eletron Transfer in DNA from Guanine and 8-Oxoguanine to a Radical Cation of the Carbohydrate Backbone
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Eletron Transfer in DNA from Guanine and 8-Oxoguanine to a Radical Cation of the Carbohydrate Backbone

机译：电子从鸟嘌呤和8-氧鸟嘌呤转移到碳水化合物骨架的阳离子上

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摘要

Photolysis of a 4ft-pivaloylsubstituted nucleotide in single- and double-stranded DNA (1) generated an enol ether radical cation 4 that was reduced to enol ether 17 by electron transfer from the nearest guanoside (G). Variation of the nucleotide sequence demonstrated a strong distance dependence of this electron-transfer rate with #beta#=1.0+-0.1 A~(-1). When 8-oxoguanosine (G~oxo) was used as the electron donor, the rate of the electron donor, the rate of the electron transfer increased by a factor of 4 but the distance dependence of the transfer remained unchanged within experimental error. In single strands, the number of intervening A, T, and C nucleotides had a much smaller effect; the rate remained nearly constant for two, three, or four intervening nucleotides. This is explained by the flexibility of the single-stranded oligonucleotides.
机译：在单链和双链DNA（4）中4ft-新戊酰取代的核苷酸的光解产生了烯醇醚自由基阳离子4，该阳离子通过电子从最近的鸟苷（G）转移而还原为烯醇醚17。核苷酸序列的变化表明该电子传输速率与＃beta＃= 1.0 + -0.1 A〜（-1）有很强的距离依赖性。当使用8-氧代鸟苷（G_oxo）作为电子供体时，电子供体的速率，电子转移的速率增加了4倍，但转移的距离依赖性在实验误差内保持不变。在单链中，中间的A，T和C核苷酸的数量影响较小;对于两个，三个或四个插入核苷酸，该速率几乎保持恒定。单链寡核苷酸的灵活性解释了这一点。

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