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首页> 外文期刊>Canadian Journal of Veterinary Research >Relevance of synovial fluid chondroitin sulphate as a biomarker to monitor polo pony joints
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Relevance of synovial fluid chondroitin sulphate as a biomarker to monitor polo pony joints

机译：滑液硫酸软骨素作为监测马球小马关节生物标志物的相关性

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摘要

Osteoarthritis (OA) of the metacarpophalangeal joint is the most common articular disease in polo ponies leading to early retirement. A biomarker that would discriminate between pathological and physiological changes secondary to exercise could be helpful in OA prevention. The aim of this study was to investigate the effects of polo training on synovial fluid biomarkers of inflammation and cartilage turnover in polo ponies of different skill levels. Synovial fluid samples were collected from metacarpophalangeal joints of polo ponies before and during the polo season (320 d). Nucleated cells, soluble protein, prostaglandin E-2 (PGE(2)), glycosaminoglycans (GAG), and urea were measured. The main synovial fluid GAG are chondroitin sulphate (CS, similar to 25 mu g/mL) and hyaluronic acid (HA, similar to 400 mu g/mL). After a polo match, a transitory increase in protein and PGE(2), but not CS and HA, occurred (expressed as urea ratio), returning to basal levels in 24 h. During the polo season, the number of synovial fluid nucleated cells was always in the normal range. Increases in protein and HA occurred during the initial 40 to 80 d, returning to basal levels afterwards. In contrast, in polo prospects the concentration of CS steadily increased during the season. Long-term follow-up revealed that the synovial fluid CS was significantly higher in polo ponies that developed joint diseases within 24 months following our study. In conclusion, CS seems to be an early marker of articular cartilage damage.
机译：掌指关节的骨关节炎（OA）是马球中最常见的关节疾病，导致人们提前退休。区分运动继发的病理和生理变化的生物标志物可能有助于预防OA。这项研究的目的是研究马球训练对不同技能水平的马球中炎症和软骨更新的滑液生物标志物的影响。在马球季节（320 d）之前和期间，从马球的掌指关节收集滑液样本。测量了有核细胞，可溶性蛋白，前列腺素E-2（PGE（2）），糖胺聚糖（GAG）和尿素。滑膜液的主要成分是硫酸软骨素（CS，约25μg / mL）和透明质酸（HA，约400μg / mL）。马球比赛后，蛋白质和PGE（2）暂时增加，但CS和HA则没有增加（表示为尿素比），并在24小时内恢复到基础水平。在马球比赛期间，滑液有核细胞的数量始终在正常范围内。蛋白质和HA的增加在最初的40到80 d内发生，此后恢复到基础水平。相反，在马球前景中，CS的浓度在整个赛季中稳定增加。长期随访显示，在我们的研究后24个月内出现关节疾病的马球中，滑液CS明显较高。总之，CS似乎是关节软骨损伤的早期标志。

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