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首页> 外文期刊>Taiwanese journal of obstetrics and gynecology >Leiomyoma and vascular endothelial growth factor gene polymorphisms: a systematic review.
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Leiomyoma and vascular endothelial growth factor gene polymorphisms: a systematic review.

机译:平滑肌瘤和血管内皮生长因子基因多态性:系统评价。

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摘要

Leiomyomas (myoma or fibroid) are the most common gynecologic tumors that occur in women of reproductive age, but their molecular pathogenesis is still unknown. Since the growth of leiomyomas involve numerous vascular factors, an association between the leiomyoma and growth factors is suspected. Vascular endothelial growth factor (VEGF) is one of the most important angiogenic growth factors. VEGF regulates angiogenesis and mediates sex steroid-induced cell growth and differentiation. VEGF-mediated activities seem to contribute to the pathogenesis of leiomyoma. Genetic variations, including polymorphisms, in VEGF might also be associated with the complex pathogenesis of leiomyomas. Here, we performed a systematic review of the roles of VEGF and its polymorphisms in the pathogenesis of leiomyoma.
机译:平滑肌瘤(肌瘤或肌瘤)是育龄妇女中最常见的妇科肿瘤,但其分子发病机理仍然未知。由于平滑肌瘤的生长涉及许多血管因子,因此怀疑平滑肌瘤与生长因子之间存在关联。血管内皮生长因子(VEGF)是最重要的血管生成生长因子之一。 VEGF调节血管生成并介导性类固醇诱导的细胞生长和分化。 VEGF介导的活性似乎有助于平滑肌瘤的发病机理。 VEGF的遗传变异,包括多态性,也可能与平滑肌瘤的复杂发病机制有关。在这里,我们对血管平滑肌瘤及其多态性在平滑肌瘤发病中的作用进行了系统的综述。

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