Removal of Fluorine from and Introduction of Fluorine into Polyhalopyridines:An Exercise in Nucleophilic Hetarenic Substitution

Carla Bobbio; Thierry Rausis; Manfred Schlosser

首页> 外文期刊>Chemistry: A European journal >Removal of Fluorine from and Introduction of Fluorine into Polyhalopyridines:An Exercise in Nucleophilic Hetarenic Substitution

【24h】

Removal of Fluorine from and Introduction of Fluorine into Polyhalopyridines:An Exercise in Nucleophilic Hetarenic Substitution

机译：从聚卤代吡啶中除去氟并将氟引入氟代吡啶中：亲核性戊二烯取代的一种运动

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

Starting from six industrially available fluorinated pyridines,an expedient access to all three tetrafluoro-pyridines (2-4),all six trifluoropyri-dines (5-10),and the five non-commercial difluoropyridines (11-14 and 16) was developed.The methods employed for the selective removal of fluorine from polyfluoropyridines were the reduction by metals or complex hydrides and the site-selective replacement by hydrazine followed by dehydrogena-tion-dediazotation or dehydrochlorina-tion-dediazotation.To introduce an extra fluorine atom,a suitable precursor was metalated and chlorinated before being subjected to a chlorine/ fluorine displacement process.

机译：从六个工业上可获得的氟化吡啶开始，开发了一种方便的途径来获取所有三个四氟吡啶（2-4），所有六个三氟吡啶（5-10）和五个非商业性二氟吡啶（11-14和16）。从多氟吡啶中选择性除去氟的方法是用金属或复合氢化物还原，然后用肼进行位点选择性置换，然后进行脱氢-脱重氮或脱氯化氢-脱重氮作用。引入一个额外的氟原子，a在进行氯/氟置换工艺之前，先对合适的前体进行金属化和氯化处理。

著录项

来源
《Chemistry: A European journal》 |2005年第6期|共8页
作者
Carla Bobbio; Thierry Rausis; Manfred Schlosser;
展开▼
作者单位

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类化学;
关键词
fluorine; hydrazino compounds; hydrogenation; metal-ation; nucleophilic substitution;

机译：氟肼化合物加氢金属化亲核取代;

相似文献

外文文献
中文文献
专利

1. Removal of Fluorine from and Introduction of Fluorine into Polyhalopyridines:An Exercise in Nucleophilic Hetarenic Substitution [J] . Carla Bobbio, Thierry Rausis, Manfred Schlosser Chemistry: A European journal . 2005,第6期

机译：从聚卤代吡啶中除去氟并将氟引入氟代吡啶中：亲核性戊二烯取代的一种运动
2. The Profound Effect of Fluorine Substitution on the Reactivity and Regioselectivity of Nucleophilic Substitution Reactions of Strained Heterocycles.A Study of Aziridine and Its Derivatives [J] . Harold D.Banks The Journal of Organic Chemistry . 2006,第21期

机译：氟取代对应变杂环亲核取代反应的反应性和区域选择性的深刻影响。氮丙啶及其衍生物的研究
3. A FACILE TWO-STEP SYNTHESIS OF (OMEGA-1)-FLUOROALKAN-OMEGA-OLIDES - INFLUENCE OF A VICINAL FLUORINE SUBSTITUENT IN NUCLEOPHILIC SUBSTITUTIONS [J] . Sattler A., Haufe G. Tetrahedron . 1996,第15期

机译：两步法合成（OMEGA-1）-氟代烷烃-OMEGA-寡核苷酸-局部氟代对核亲核取代基的影响
4. NUCLEOPHILIC F-18 FLUORINATION FOR BIOCONJUGATION CHEMISTRY: ITS APPLICATIONS TO IMAGING AGNETS [C] . Dae Yoon Chi, Byoung Se Lee, Hyejin Ahn, 8th International Conference on Isotopes 2014 . 2014

机译：核亲F-18氟化法在生物共轭化学中的应用及其在成像试剂中的应用
5. Characterizations of fluorine-superconductors and selected fluorine -compounds, vanadium oxydiphosphate by fluorine-19, carbon-13, proton, phosphorus-31 NMR and a new probe for multiple pulse, MAS and DAS NMR. [D] . Pan, Hongjun. 1991

机译：用氟19，碳13，质子，磷31 NMR表征氟超导体和选定的氟化合物，氧合二磷酸钒，并采用多脉冲，MAS和DAS NMR的新探针。
6. Synthesisand Late-Stage Functionalization of ComplexMolecules through C–H Fluorination and Nucleophilic AromaticSubstitution [O] . PatrickS. Fier, John F. Hartwig, * -1

机译：合成的后期和后期功能化通过C–H氟化和亲核芳香族分子代换
7. The Profound Effect of Fluorine Substitution on the Reactivity and Regioselectivity of Nucleophilic Substitution Reactions of Strained Heterocycles. A Study of Aziridine and Its Derivatives [O] . -1

机译：氟取代对应变杂环亲核取代反应的反应性和区域选择性的深厚作用。 Aziridine及其衍生物的研究

Removal of Fluorine from and Introduction of Fluorine into Polyhalopyridines:An Exercise in Nucleophilic Hetarenic Substitution

摘要

著录项

相似文献

相关主题

期刊订阅