...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Pathology Research and Practice >Matrix metalloproteinase-2 expression in laryngeal preneoplastic and neoplastic lesions.
【24h】

Matrix metalloproteinase-2 expression in laryngeal preneoplastic and neoplastic lesions.

机译：基质金属蛋白酶2在喉癌前病变和肿瘤病变中的表达。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Matrix metalloproteinase-2 (MMP-2), a member of gelatinases, is particularly important in the digestion of nonfibrillary and denaturated collagens; thus, it may play a role in tissue remodeling and in the invasion of malignant cells. The expression of MMP-2 has not yet been described in preneoplastic lesions of the larynx thus far. The purpose of this study was to evaluate whether the expression of MMP-2 plays a role in early laryngeal carcinogenesis. Laryngectomy specimens of 20 invasive carcinoma cases were studied. The slides with atypical hyperplasia, carcinoma in situ, and invasive carcinoma were selected from laryngectomy specimens. On these slides, 23 atypical hyperplasia and 17 carcinoma in situ areas were identified. MMP-2 expression was scored immunohistochemically on paraffin tissue sections using the avidin-biotin-peroxidase method. MMP-2 expression in all three groups was statistically different. A sequential increase in MMP-2 expression correlated significantly with the hypothesis of multistep carcinogenesis. In contrast, MMP-2 expression was not related to tumor stage, lymph node metastasis, or differentiation in squamous cell carcinomas. In conclusion, this sequential increase in MMP-2 expression points to an altered expression of MMP-2 in early neoplastic transformation in laryngeal mucosa, followed by an increasing expression during the progression of the disease.
机译：基质金属蛋白酶2（MMP-2）是明胶酶的成员，在非原纤维和变性胶原的消化中特别重要。因此，它可能在组织重塑和恶性细胞侵袭中起作用。到目前为止，尚未在喉癌前病变中描述MMP-2的表达。这项研究的目的是评估MMP-2的表达是否在早期喉癌发生中起作用。研究了20例浸润性癌的喉切除标本。从喉切除标本中选择具有非典型增生，原位癌和浸润性癌的载玻片。在这些幻灯片上，鉴定出23个非典型增生和17个原位癌。使用抗生物素蛋白-生物素-过氧化物酶方法对石蜡组织切片上的MMP-2表达进行免疫组织化学评分。所有三组中的MMP-2表达在统计学上均不同。 MMP-2表达的顺序增加与多步癌变的假设相关。相反，在鳞状细胞癌中，MMP-2表达与肿瘤分期，淋巴结转移或分化无关。总之，MMP-2表达的这种顺序增加表明喉粘膜早期肿瘤转化中MMP-2的表达发生了改变，随后在疾病进展过程中表达增加。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号