Expression of cancer stem cell markers in metastatic colorectal cancer correlates with liver metastasis, but not with metastasis to the central nervous system

Michl Marlies; Heinemann Volker; Jung Andreas; Engel Jutta; Kirchner Thomas; Neumann Jens

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Expression of cancer stem cell markers in metastatic colorectal cancer correlates with liver metastasis, but not with metastasis to the central nervous system

机译：转移性结直肠癌中癌症干细胞标志物的表达与肝转移有关，但与中枢神经系统转移无关

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Introduction: In colorectal cancer (CRC), metastatic spread is supposed to be mainly driven by tumor cells with stem cell features. Only about 1% of all CRC patients develop metastasis to the central nervous system (CNS). The present study intended to analyze the correlation between the expression of cancer stem cell markers and patterns of liver or CNS metastases.

机译：简介：在大肠癌（CRC）中，转移性扩散主要由具有干细胞特征的肿瘤细胞驱动。所有CRC患者中只有约1％转移到中枢神经系统（CNS）。本研究旨在分析癌症干细胞标志物的表达与肝脏或中枢神经系统转移模式之间的相关性。

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《Pathology Research and Practice》 |2015年第8期|共9页
作者
Michl Marlies; Heinemann Volker; Jung Andreas; Engel Jutta; Kirchner Thomas; Neumann Jens;
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正文语种 eng
中图分类病理学;
关键词
Colorectal cancer; Brain metastasis; Liver metastasis; CD133; CD44; beta-Catenin;

机译：大肠癌;脑转移;肝转移;CD133;CD44;β-连环蛋白;

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1. Expression of cancer stem cell markers in metastatic colorectal cancer correlates with liver metastasis, but not with metastasis to the central nervous system [J] . Michl Marlies, Heinemann Volker, Jung Andreas, Pathology Research and Practice . 2015,第8期

机译：转移性结直肠癌中癌症干细胞标志物的表达与肝转移有关，但与中枢神经系统转移无关
2. Identification of single nucleotide polymorphisms of the PI3K-AKT-mTOR pathway as a risk factor of central nervous system metastasis in metastatic breast cancer [J] . Le Rhun Emilie, Bertrand Nicolas, Dumont Aurelie, European journal of cancer: official journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR) . 2017,第期

机译：PI3K-AKT-mTOR途径单核苷酸多态性作为转移性乳腺癌中枢神经系统转移的危险因素
3. Risk factors for central nervous system metastasis in patients with metastatic breast cancer [J] . Canfeza Sezgin MD, Erhan Gokmen, Mustafa Esassolak, Medical Oncology . 2007,第2期

机译：转移性乳腺癌患者中枢神经系统转移的危险因素
4. Expression of Osteopontin In Human Gastric Cancer Cell Lines Has a High Correlation with Liver Metastasis [C] . H. Nishimori, K. Ohno, F. Hata, World Congress of the International College of Surgeons . 2004

机译：骨桥蛋白在人胃癌细胞系中的表达与肝转移相关
5. Comparative Analysis on Innate Immune System Function in Metastatic Breast, Colorectal, and Prostate Cancer Patients with Circulating Tumor Cells [D] . Santos, Mark Anthony Francisco. 2014

机译：转移性乳腺癌，结直肠癌和前列腺癌患者循环肿瘤细胞先天免疫系统功能的比较分析
6. Central nervous system metastasis secondary to colorectal cancer: a retrospective cohort study of 20 cases [O] . Sebastián Mondaca, Valentina Hornig, Pablo Munoz-Schuffenegger, 2016

机译：大肠癌继发的中枢神经系统转移：20例回顾性队列研究
7. Central Nervous System Metastasis in Patients with HER2-Positive Metastatic Breast Cancer: Patient Characteristics, Treatment, and Survival from SystHERs [O] . Sara A. Hurvitz, Joyce OShaughnessy, Ginny Mason, 2018

机译：HER2阳性转移性乳腺癌患者中枢神经系统转移：SYSTHERS的患者特征，治疗和生存

Expression of cancer stem cell markers in metastatic colorectal cancer correlates with liver metastasis, but not with metastasis to the central nervous system

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