Highly efficient synthesis of enantiopure diacetylated C-2-symmetric diols by ruthenium- and enzyme-catalyzed dynamic kinetic asymmetric transformation (DYKAT)

Martin-Matute B; Edin M; Backvall JE

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Highly efficient synthesis of enantiopure diacetylated C-2-symmetric diols by ruthenium- and enzyme-catalyzed dynamic kinetic asymmetric transformation (DYKAT)

机译：通过钌和酶催化的动态动力学不对称转化（DYKAT）高效合成对映体纯的二乙酰化C-2-对称二醇

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Highly efficient synthesis of enantiopure diacetates of 2,4-pentanediol and 2,5-hexanediol starting from commercially available mixtures of the diols (dl/meso approximate to 1:1) has been realized by combining a fast ruthenium-catalyzed epimerization with an enzymatic transesterification. The in situ coupling of these two processes produces the diacetates in high yield in > 99% enantiomeric excess.

机译：通过将快速钌催化的差向异构化与酶促反应相结合，已经从二醇的市售混合物（dl / meso近似于1：1）开始高效合成2,4-戊二醇和2,5-己二醇的对映体纯二乙酸酯。酯交换。这两个过程的原位偶联以高收率产生＞ 99％对映体过量的二乙酸酯。

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《Chemistry: A European journal》 |2006年第23期|共9页
作者
Martin-Matute B; Edin M; Backvall JE;
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正文语种 eng
中图分类化学;
关键词
diols; dynamic kinetic asymmetric transformations enzymes; kinetic resolution; racemization; GAMMA-HYDROXY KETONES; SECONDARY ALCOHOLS; AMBIENT-TEMPERATURE; METAL CATALYSIS; RACEMIZATION CATALYSTS; QUANTITATIVE-ANALYSES; PROTON-TRANSFER; RESOLUTION; LIPASE; HYDRIDE;

机译：二醇;动态动力学不对称转化酶;动力学拆分;消旋;GAMMA-羟基酮;二次醇;环境温度;金属催化;芳构化催化剂;定量分析;质子转移;拆分;脂质;氢化;

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1. Highly efficient synthesis of enantiopure diacetylated C-2-symmetric diols by ruthenium- and enzyme-catalyzed dynamic kinetic asymmetric transformation (DYKAT) [J] . Martin-Matute B, Edin M, Backvall JE Chemistry: A European journal . 2006,第23期

机译：通过钌和酶催化的动态动力学不对称转化（DYKAT）高效合成对映体纯的二乙酰化C-2-对称二醇
2. Amino acid-catalyzed dynamic kinetic asymmetric transformations (DYKAT): one-step de novo synthesis of polyketide sugars from racemic beta-hydroxy aldehydes [J] . Reyes E, Cordova A Tetrahedron letters: The International Journal for the Rapid Publication of Preliminary Communications in Organic Chemistry . 2005,第39期

机译：氨基酸催化的动态动力学不对称转化（DYKAT）：由外消旋β-羟基醛一步一步合成聚酮糖
3. Amino acid-catalyzed dynamic kinetic asymmetric transformations (DYKAT): one-step de novo synthesis of polyketide sugars from racemic beta-hydroxy aldehydes [J] . Reyes E, Cordova A Tetrahedron letters: The International Journal for the Rapid Publication of Preliminary Communications in Organic Chemistry . 2005,第39期

机译：氨基酸催化的动态动力学不对称转化（DYKAT）：由外消旋β-羟基醛一步一步合成聚酮糖
4. Catalytic Asymmetric Synthesis of Erythro-P-hydroxy Amino Acids through Dynamic Kinetic Resolution [C] . Takavuki Goto, Yasuhiro Hiroki, Osamu Hara, Symposium on Organometallic Chemistry . 2003

机译：动态动力学分辨率催化不对称合成红霉 - 羟基氨基酸
5. Development of new dynamic kinetic asymmetric transformations: Asymmetric allylic alkylations of allenes, vinylaziridines and progress towards the total synthesis of lasonolide A. [D] . Fandrick, Daniel Robert. 2006

机译：新的动态动力学不对称转化的发展：艾伦，乙烯基氮丙啶的不对称烯丙基烷基化以及向Lasonolide A的全合成方向发展。
6. Asymmetric Catalysis Special Feature Part II: One-pot synthesis of enantiopure syn-13-diacetates from racemic syn/anti mixtures of 13-diols by dynamic kinetic asymmetric transformation [O] . Michaela Edin, Johannes Steinreiber, Jan-E. Bäckvall 2004

机译：不对称催化的特征第二部分：通过动态动力学不对称转化由13-二醇的外消旋同/反混合物一锅合成对映体纯的1-13-二乙酸酯
7. One-pot synthesis of enantiopure syn-1,3-diacetates from racemic syn/anti mixtures of 1,3-diols by dynamic kinetic asymmetric transformation [O] . Edin, Michaela, Steinreiber, Johannes, Bäckvall, Jan-E. 2004

机译：通过动态动力学不对称转化从1,3-二醇的外消旋式正/反混合物一锅合成对映体纯-1,3-二乙酸酯

Highly efficient synthesis of enantiopure diacetylated C-2-symmetric diols by ruthenium- and enzyme-catalyzed dynamic kinetic asymmetric transformation (DYKAT)

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