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首页> 外文期刊>The American journal of otology >A subpopulation of Meniere's patients produce antibodies that bind to endolymphatic sac antigens.
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A subpopulation of Meniere's patients produce antibodies that bind to endolymphatic sac antigens.

机译：美尼尔氏病患者的亚群产生与内淋巴囊抗原结合的抗体。

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摘要

The endolymphatic sac (ES) has been suggested to serve an important immunological role within the inner ear. Meanwhile, immunological mechanisms have been studied in connection with Meniere's disease. The aim of this study is to look for and recognize antibodies against the ES in the sera of patients with Meniere's disease, using the technique of indirect immunofluorescence. Sera from 50 patients with Meniere's disease, from an animal model of autoimmune inner ear disease, and from healthy controls were tested against ES tissue substrates obtained from guinea pigs. Immunoglobulin deposition in the ES was found in 20 patients (40%) compared with one control (10%). The difference was statistically significant when computing the odds ratios at 95% confidence level. Fluorescein labeling was demonstrated in the ES epithelium in 16% and in the surrounding perisaccular stroma in 24%. Identical immunoreactivity against the ES tissue was depicted in the sera of the experimental animal model. These findings support the possibility of humoral immunological involvement in the Meniere's disease process. Immunological derangement of the ES function could be the first step in a cascade of reactions leading to endolymphatic hydrops and presenting as Meniere's disease.
机译：已建议内淋巴囊（ES）在内耳中起重要的免疫作用。同时，已经研究了与美尼尔氏病有关的免疫学机制。这项研究的目的是使用间接免疫荧光技术在梅尼埃病患者的血清中寻找和识别针对ES的抗体。针对从豚鼠获得的ES组织底物，对50例美尼尔氏病患者，自身免疫性内耳疾病的动物模型以及健康对照的血清进行了测试。与一名对照（10％）相比，在20名患者（40％）中发现了ES中的免疫球蛋白沉积。当在95％置信水平下计算比值比时，差异具有统计学意义。荧光素标记在ES上皮中有16％，在周围的囊周围基质中有24％。在实验动物模型的血清中描述了针对ES组织的相同免疫反应性。这些发现支持体液免疫学参与美尼尔氏病过程的可能性。 ES功能的免疫紊乱可能是导致内淋巴积液并呈梅尼埃病的一系列反应的第一步。

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