...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The American journal of otology >Ossicular chain reconstruction using a new tissue adhesive.
【24h】

Ossicular chain reconstruction using a new tissue adhesive.

机译：使用新的组织粘合剂重建听骨链。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

HYPOTHESIS: A new medical-grade cyanoacrylate tissue adhesive will improve the results of ossicular chain reconstruction in a rat model. BACKGROUND: An ideal tissue adhesive has long been awaited by otologists. Studies examining the older cyanoacrylates have demonstrated variable efficacy and toxicity. Octylcyanoacrylate is a new tissue adhesive that has many ideal properties for otologic surgery. METHODS: Thirteen female C-D rats were anesthetized, and preoperative auditory brainstem response (ABR) testing was performed. A left antrotomy was performed, and the incus was removed. In the adhesive group, the incus was dipped in octylcyanoacrylate and interposed between the tympanic membrane and the stapes; no adhesive was used in the control group. At 8 weeks, postoperative ABR was performed, the integrity of the ossicular chain inspected, and histopathologic analysis of the temporal bones performed. Statistical comparison of ABR results was performed with the Mann-Whitney test. RESULTS: Seven rats were randomized to the adhesive group and six to the control group, of which four survived. There were no histopathologic differences in the temporal bones of the animals other than the presence of mild foreign body reaction around the ossicular chain of the animals in the adhesive group. The ossicular chain was not intact in two of the four controls, whereas the rest were intact at 8 weeks. Postoperative air conduction ABR results (mean dB sound pressure level) (62.5 control versus 34.3 adhesive, p = 0.010) and air-bone gaps (47.5 control versus 18.9 adhesive, p = 0.008) were significantly better in the adhesive group. CONCLUSIONS: This new medical-grade tissue adhesive improves the hearing results of ossicular chain reconstruction, with no apparent histotoxicity in this animal model.
机译：假设：一种新型的医用级氰基丙烯酸酯组织粘合剂将改善大鼠模型中听骨链重建的结果。背景技术：理想的组织粘合剂早已被耳科医生所期待。研究较老的氰基丙烯酸酯的研究表明其可变性和毒性。氰基丙烯酸辛酯是一种新型的组织粘合剂，对耳科手术具有许多理想的性能。方法：麻醉13只雌性C-D大鼠，并进行术前听性脑干反应（ABR）测试。进行了左解剖术，并去除了砧骨。在粘合剂组中，将砧骨浸入氰基丙烯酸辛酯中，并插入鼓膜和骨之间。对照组不使用粘合剂。在第8周，进行了术后ABR，检查了听骨链的完整性，并对颞骨进行了组织病理学分析。使用Mann-Whitney检验对ABR结果进行统计比较。结果：将7只大鼠随机分为粘连组，另6只随机分为对照组，其中4只存活。除了粘附组中动物的听骨链周围存在轻度异物反应外，动物的颞骨没有组织病理学差异。在四个对照中的两个中，听骨链没有完整，而其余的在第8周时完整。术后空气传导ABR结果（平均dB声压级）（62.5对照对比34.3粘合剂，p = 0.010）和气隙（47.5对照对比18.9粘合剂，p = 0.008）明显好于粘合剂组。结论：这种新型医学级组织粘合剂改善了听骨链重建的听力结果，在该动物模型中没有明显的组织毒性。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号