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首页> 外文期刊>The American Journal of Surgery >Age-related clinicopathologic and molecular features of patients receiving curative hepatectomy for hepatocellular carcinoma
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Age-related clinicopathologic and molecular features of patients receiving curative hepatectomy for hepatocellular carcinoma

机译：根治性肝切除术治疗肝细胞癌患者的年龄相关临床病理和分子特征

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Background Age-related differences of clinicopathologic features, outcomes, and molecular properties of hepatocellular carcinoma remain unclarified. Methods We classified patients who underwent hepatectomy for hepatocellular carcinoma into 3 groups by age bracket; younger group (<50 years), middle-aged group (50 to 79 years), and elderly group (≥80 years) and compared age-related features. Results Hepatitis viral infection was dominant in the younger group (hepatitis B virus [HBV]; 67%) and middle-aged group (hepatitis C virus [HCV]; 56%), whereas the elderly group showed a significantly higher rate without hepatitis virus infection (absence of HBV and HCV infection, 66%; P =.0001). There was a significantly greater proportion of age-associated pre-existing comorbidity in the elderly group (89%; P =.0004). Liver cirrhosis in the elderly group (24%) was significantly lower than other groups (younger, 67%; middle-aged, 50%; P =.0058). There was no significant difference in perioperative and postoperative outcomes among these groups. Microarray analysis revealed age-related upregulation of androgen and phosphatidylinositol 3-kinase pathways in the tumor tissue and downregulation of the fibrosis-related pathways in the noncancerous liver tissue. Conclusions Based on increased correlation with the absence of HBV and HCV infection and pre-existing comorbidity, the age-related carcinogenic pathways might play a critical role in elderly hepatocarcinogenesis.
机译：背景肝细胞癌的临床病理特征，预后和分子特性与年龄相关的差异尚不清楚。方法按年龄段将肝癌肝切除术患者分为3组。年龄较小的组（<50岁），中年组（50至79岁）和老年人组（≥80岁），并比较了与年龄相关的特征。结果年轻组（乙型肝炎病毒[HBV]; 67％）和中年组（丙型肝炎病毒[HCV]; 56％）以肝炎病毒感染为主，而老年组无肝炎病毒的感染率更高感染（不存在HBV和HCV感染，占66％; P = .0001）。在老年组中，与年龄相关的既存合并症比例显着更高（89％; P = .0004）。老年组肝硬化（24％）显着低于其他组（年轻人67％;中年人50％; P = .0058）。这些组的围手术期和术后结局无明显差异。微阵列分析揭示了肿瘤组织中雄激素和磷脂酰肌醇3-激酶途径的年龄相关上调以及非癌性肝组织中纤维化相关途径的下调。结论基于与不存在HBV和HCV感染以及既存合并症的相关性增加，年龄相关的致癌途径可能在老年人肝癌的发生中起关键作用。

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