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首页> 外文期刊>The American Journal of Surgery >Risk factors for central neck lymph node metastasis of clinically noninvasive, node-negative papillary thyroid microcarcinoma
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Risk factors for central neck lymph node metastasis of clinically noninvasive, node-negative papillary thyroid microcarcinoma

机译：临床无创，淋巴结阴性的甲状腺乳头状甲状腺癌的中央颈淋巴结转移的危险因素

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Background To examine predictive factors for subclinical central neck lymph node metastases (LNM) of papillary thyroid microcarcinoma (PTMC). Methods The clinical and pathological findings of 287 patients with clinically noninvasive, node-negative, solitary papillary thyroid carcinoma (PTC), who had undergone thyroidectomy plus central compartment neck dissection and showed pathologically confirmed nodal metastases, were analyzed. Predictive risk factors for central LNM were quantified. Results Pathologic LNM was identified in 63 (32.6%) PTMC patients and 48 (51.0%) PTC patients (tumor size >1 cm; P =.003). Tumor size (>.7 cm; P =.011), multifocality (P =.010), and microscopic extracapsular extension (P =.050) were significant variables predictive of central LNM from PTMC in univariate analysis. Tumor size (odds ratio 2.28, 95% confidence interval 1.19 to 4.38; P =.014) and multifocality (odds ratio 2.38, 95% confidence interval 1.14 to 4.93; P =.020) were independent variables predictive of central LNM in multivariate analysis. Conclusions Cervical LNM is highly prevalent in clinically noninvasive, node-negative PTC. Central neck LNM is associated with larger tumor size and multifocality of PTMC.
机译：背景研究检查甲状腺乳头状甲状腺癌（PTMC）的亚临床中心颈淋巴结转移（LNM）的预测因素。方法对287例行甲状腺切除术加中央隔室颈淋巴结清扫术并经病理证实为淋巴结转移的临床无创，淋巴结阴性，孤立性乳头状甲状腺癌（PTC）患者的临床和病理结果进行分析。量化中央LNM的预测风险因素。结果在63例（32.6％）PTMC患者和48例（51.0％）PTC患者中发现了病理学LNM（肿瘤大小> 1 cm; P = .003）。在单变量分析中，肿瘤大小（> .7 cm; P = .011），多灶性（P = .010）和镜下囊外扩张（P = .050）是预测PTMC中心LNM的重要变量。肿瘤大小（比值比2.28，95％置信区间1.19至4.38; P = .014）和多焦点性（比值比2.38，95％置信区间1.14至4.93; P = .020）是预测多变量分析中中心LNM的独立变量。 。结论宫颈LNM在临床上无创，淋巴结阴性PTC中非常普遍。中央颈部LNM与更大的肿瘤大小和PTMC的多灶性有关。

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