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首页> 外文期刊>The American Journal of Tropical Medicine and Hygiene >BOne marrow parasite burden among patients with new world kala-azar is associated with disease severity
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BOne marrow parasite burden among patients with new world kala-azar is associated with disease severity

机译：新世界黑热病患者的骨髓寄生负担与疾病严重程度相关

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摘要

Kala-azar or visceral leishmaniasis, found mostly throughout the Indian Subcontinent, East Africa, and Brazil, kills 20,000-40,000 persons annually. The agents, Leishmania donovani and Leishmania infantum, are obligatory intracellular protozoa of mononuclear phagocytes found principally in the spleen and bone marrow. Protracted fever, anemia, wasting, hepatosplenomegaly, hemorrhages, and bacterial co-infections are typical features. One hundred and twenty-two (122) in-hospital patients were studied to verify if higher bone marrow parasite load estimated by quantitative polymerase chain reaction is associated with severe disease. The estimated median parasite load was 5.0 parasites/106 human nucleated cells. It is much higher in deceased than among survivors (median 75.0 versus 4.2). Patients who lost more weight had a higher parasite burden, as well as patients with epistaxis, abdominal pain, edema, and jaundice. This study suggests that higher parasite load is influenced by wasting, which may lead to more severe disease.
机译：黑热病或内脏利什曼病主要分布于印度次大陆，东非和巴西，每年造成20,000至40,000人死亡。利什曼原虫和诺氏利什曼原虫是主要存在于脾脏和骨髓中的单核吞噬细胞的强制性细胞内原生动物。长期发烧，贫血，消瘦，肝脾肿大，出血和细菌合并感染是典型特征。对一百二十二（122）名住院患者进行了研究，以验证通过定量聚合酶链反应估计的较高的骨髓寄生虫负荷是否与严重疾病相关。估计的中位寄生虫负荷为5.0寄生虫/ 106个人类有核细胞。死者比幸存者要高得多（中位数75.0对4.2）。体重减轻的患者以及鼻出血，腹痛，水肿和黄疸的患者具有较高的寄生虫负担。这项研究表明，较高的寄生虫负荷受浪费的影响，这可能导致更严重的疾病。

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