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首页> 外文期刊>The American Journal of Tropical Medicine and Hygiene >Emergence and clearance of gametocytes in uncomplicated Plasmodium falciparum malaria.
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Emergence and clearance of gametocytes in uncomplicated Plasmodium falciparum malaria.

机译：单纯性恶性疟原虫疟疾中配子细胞的出现和清除。

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We reviewed the records of 1,175 patients with uncomplicated Plasmodium falciparum malaria to determine the prevalence of gametocytemia. All patients were admitted and received artemisinin combination therapy. Blood films were checked daily until discharge. Circulating gametocytes were observed in 240 (20.2%) of patients and in most cases (222 of 240, 92.5%) gametocytemia was detected during the first 24 hours after admission. Gametocytes were first seen in 174 cases on admission, in 24 cases at 12 hours, and in 24 cases at 24 hours. The longest interval between admission and first appearance of gametocytes was 192 hours. The median gametocyte clearance time was 163 hours (range = 12-806) in the 219 patients in whom gametocytemia resolved. However, 21 patients (9.8%) still had gametocytemia on discharge. Gametocytemia generally is present within the first 24 hours after admission, and emerges in only 1.9% of patients later on during treatment with artemisinin.
机译：我们回顾了1,175例单纯性恶性疟原虫疟疾患者的记录，以确定配子细胞减少症的患病率。所有患者均入院并接受青蒿素联合治疗。每天检查血膜直至排出。在入院后的最初24小时内，有240名（20.2％）的患者观察到循环配子细胞，大多数情况下（240例中的222例，占92.5％）。入院时首次发现配子细胞是174例，在12小时时是24例，在24小时时是24例。入院与配子细胞首次出现之间的最长间隔为192小时。在219名配子细胞减少症患者中，配子细胞清除时间的中位数为163小时（范围= 12-806）。但是，有21名患者（9.8％）出院时仍患有配子细胞减少症。配子细胞减少症通常在入院后24小时内出现，在青蒿素治疗期间仅在1.9％的患者中出现。

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