...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The American Journal of Tropical Medicine and Hygiene >Distinguishing visceral leishmaniasis from intolerance to pegylated interferon-alpha in a thalassemic splenectomized patient treated for chronic hepatitis C.
【24h】

Distinguishing visceral leishmaniasis from intolerance to pegylated interferon-alpha in a thalassemic splenectomized patient treated for chronic hepatitis C.

机译：在治疗慢性丙型肝炎的地中海贫血患者中，将内脏利什曼病从不耐受转变为聚乙二醇化干扰素-α。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

A 37-year-old splenectomized man affected by beta-thalassemia and chronic hepatitis, recently treated with pegylated interferon-alpha (Peg-IFN), was admitted because of elevated fever lasting 3 months and unresponsiveness to broad-spectrum antibiotics. Laboratory studies showed white blood cell and platelet counts within the normal range but lower than observed before Peg-IFN treatment and an elevated erythrocyte sedimentation rate. The blood transfusion rate was reported to be increased compared with the period preceding Peg-IFN treatment. A diagnosis of visceral leishmaniasis (VL) was made after Leishmania amastigotes were identified from Giemsa-stained smears of bone marrow aspirates. Cure occurred after liposomal amphotericin B was administered. Symptoms of VL may be difficult to distinguish from the manifestations of Peg-IFN intolerance. We suggest that VL must be suspected in any immunodepressed patient with an unexplained fever and a history of exposure in an endemic area.
机译：由于持续3个月的高烧持续以及对广谱抗生素的反应迟钝，最近接受了聚乙二醇化干扰素-α（Peg-IFN）治疗的37岁的受β地中海贫血和慢性肝炎影响的脾切除术男子入院。实验室研究表明，白细胞和血小板计数在正常范围内，但低于Peg-IFN治疗前观察到的水平，并且红细胞沉降率升高。据报道与Peg-IFN治疗之前相比，输血率增加了。在从吉姆萨染色的骨髓穿刺涂片中鉴定出利什曼原虫后，便诊断出内脏利什曼病。脂质体两性霉素B给药后治愈。 VL的症状可能难以与Peg-IFN不耐受的表现区分开。我们建议，对于任何无法解释的发烧且在流行地区有暴露史的免疫抑制患者，都必须怀疑VL。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号