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首页> 外文期刊>The American Journal of Tropical Medicine and Hygiene >Atovaquone plus proguanil versus halofantrine for the treatment of imported acute uncomplicated Plasmodium falciparum malaria in non-immune adults: a randomized comparative trial.
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Atovaquone plus proguanil versus halofantrine for the treatment of imported acute uncomplicated Plasmodium falciparum malaria in non-immune adults: a randomized comparative trial.

机译：Atovaquone联合Proguanil与halantantrine联合治疗非免疫性成年人中进口的急性单纯性恶性疟原虫疟疾：一项随机对照试验。

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摘要

In endemic zones, the atovaquone-proguanil (AP) combination is well tolerated and effective in treating acute, uncomplicated malaria. Trials involving non-immune patients are lacking, however. We conducted a randomized, multicenter open-label trial to determine the efficacy and tolerability of the AP combination (1,000 mg + 400 mg once daily for 3 days) in comparison with halofantrine (HF) (1,500 mg in 3 doses) in non-immune adults with imported uncomplicated Plasmodium falciparum malaria. Follow-up visits were programmed on Days 7, 14, 21, 28, and 35 after hospital discharge. Out of 48 patients enrolled in the study, 41 were assessable for the cure rate (21 in the AP group and 20 in the HF group). All the patients were cured. The mean parasite clearance time was longer (63+/-23 hours) in the AP group than in the HF group (48+/-15 hours) (P = 0.02). The frequency of gastrointestinal adverse events was higher in the AP group. No noteworthy electrocardiographic changes were observed, particularly in the QTc interval. The AP combination appears to be a valuable alternative treatment in non-immune adults.
机译：在地方性地区，阿托伐醌-鸟嘌呤（AP）组合具有良好的耐受性，可有效治疗急性，简单的疟疾。但是，缺乏涉及非免疫患者的试验。我们进行了一项随机，多中心的开放标签试验，以确定与非免疫性氟替林（HF）（3剂量1,500 mg）相比，AP组合（1,000 mg + 400 mg每天一次，共3天）的疗效和耐受性成人并发单纯性恶性疟原虫疟疾。出院后的第7、14、21、28和35天进行了随访。在该研究的48位患者中，有41位患者的治愈率可评估（AP组21例，HF组20例）。所有患者均cured愈。 AP组的平均寄生虫清除时间（63 +/- 23小时）比HF组（48 +/- 15小时）更长（P = 0.02）。 AP组胃肠道不良事件的发生率较高。没有观察到值得注意的心电图变化，尤其是在QTc间隔内。在非免疫成人中，AP组合似乎是有价值的替代疗法。

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