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首页> 外文期刊>The American Journal of Tropical Medicine and Hygiene >Expression of filarial-specific IgG subclasses under different transmission intensities in a region endemic for loiasis.
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Expression of filarial-specific IgG subclasses under different transmission intensities in a region endemic for loiasis.

机译：丝虫病流行区不同传播强度下丝状特异性IgG亚类的表达。

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摘要

Specific IgG subclasses were investigated in two villages (Okoumbi and Ndjokaye) in southeast Gabon with different Loa loa transmission intensities of approximately 9,000 and 1,300 infective larvae (L3) per person per year, respectively. IgG subclasses were measured by an enzyme-linked immunosorbent assay (ELISA) using extracts of L. loa L3, microfilariae (MF), or adult worms. Levels of L3-specific IgG3 were significantly higher in the village with low transmission (Ndjokaye) (P = 0.006). In contrast, MF-specific IgG2 was significantly higher in Okoumbi than in Ndjokaye (P = 0.0009). In the high-transmission village (Okoumbi), levels of both MF- and adult-specific IgG4 were significantly increased in MF carriers compared with amicrofilaremic subjects (P = 0.0015 and P = 0.003, respectively), while levels of L3- and MF-specific IgG1 were significantly higher in amicrofilaremic individuals compared with MF carriers (P = 0.04 and P = 0.03, respectively). Furthermore, among microfilaremic individuals, the level of the specific IgG1 subclass was much lower in Okoumbi than in Ndjokaye (P = 0.036). These results suggest that the expression of antigen-specific IgG3 and IgG2 is more likely to vary with transmission intensity, whereas antigen-specific IgG4 and IgG1 varies with adult worm and MF burden.
机译：在加蓬东南部的两个村庄（Okoumbi和Ndjokaye）对特定的IgG亚类进行了调查，它们的Loa loa传播强度不同，分别为每人每年约9,000和1300感染性幼虫（L3）。 IgG亚类通过酶联免疫吸附测定（ELISA）使用L. loa L3，微丝aria（MF）或成虫蠕虫的提取物进行测量。在低传播（Ndjokaye）的村庄中，L3特异性IgG3的水平明显更高（P = 0.006）。相反，Okoumbi的MF特异性IgG2明显高于Ndjokaye（P = 0.0009）。在高传播村（Okoumbi），MF携带者的MF特异性和成人特异性IgG4的水平与微丝菌血症受试者相比显着增加（分别为P = 0.0015和P = 0.003），而L3-和MF-的水平与MF携带者相比，微丝蛋白血症个体的特异性IgG1显着更高（分别为P = 0.04和P = 0.03）。此外，在微丝虫患者中，Okoumbi中特异性IgG1亚类的水平比Ndjokaye中低得多（P = 0.036）。这些结果表明，抗原特异性IgG3和IgG2的表达更可能随传播强度而变化，而抗原特异性IgG4和IgG1的表达随成虫和MF负荷而变化。

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