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首页> 外文期刊>The American Journal of Tropical Medicine and Hygiene >Development of a model of hookworm infection exhibiting salient characteristics of human infection.
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Development of a model of hookworm infection exhibiting salient characteristics of human infection.

机译：展现出人类感染的显着特征的钩虫感染模型的开发。

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Patent and pathologic infections of the human hookworm Necator americanus were established in the common marmoset (Callithrix jacchus). In a pilot study, a laboratory strain of N. americanus was compared with a fresh field isolate. Pathology was more severe in animals infected with a fresh isolate. In all animals, infection was associated with increased total plasma IgE and production of IgG specific to adult worm excretory/secretory (ES) products. Histamine was released by basophils in response to IgE, ES products, and a recombinant hookworm allergen, calreticulin. The pilot study indicated the potential of this animal model of hookworm infection and led us to investigate the consequences of infecting a further cohort with the fresh field isolate. This second study confirmed our initial findings, that it is possible to investigate the human hookworm N. americanus in a model exhibiting many of the characteristics of the immunology of hookworm infection in its definitive host.
机译：在普通mar猴（Callithrix jacchus）中发现了人类钩虫美洲轮虫的专利和病理感染。在一项初步研究中，将美国猪笼草的实验室菌株与新鲜田间分离株进行了比较。在感染了新鲜分离株的动物中，病理学更为严重。在所有动物中，感染与总血浆IgE增加和成虫蠕虫排泄/分泌（ES）产品特异的IgG产生有关。组胺由嗜碱性粒细胞释放，以响应IgE，ES产物和重组钩虫变应原钙网蛋白。初步研究表明了这种钩虫感染动物模型的潜力，并引导我们研究了用新鲜田间分离株感染另一个人群的后果。这项第二项研究证实了我们的初步发现，即可以在模型中研究人类钩虫N. Americanus，该模型在其最终宿主中表现出钩虫感染免疫学的许多特征。

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