...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The American Journal of Tropical Medicine and Hygiene >Urine antigen detection for the diagnosis of human neurocysticercosis.
【24h】

Urine antigen detection for the diagnosis of human neurocysticercosis.

机译：尿液抗原检测可用于诊断人神经囊虫病。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Neurocysticercosis (NCC) is a major cause of seizures and epilepsy. Diagnosis is based on brain imaging, supported by immunodiagnosis in serum or cerebrospinal fluid (CSF). Lumbar puncture is invasive and painful. Blood sampling is slightly painful and poorly accepted. Urine antigen detection has been used for other parasites and tried in NCC with suboptimal performance. We used a monoclonal antibody-based ELISA to detect Taenia solium antigens in urine from 87 Peruvian neurocysticercosis patients (viable cysts, N = 34; subarachnoid cysticercosis, N = 10; degenerating parasites, N = 7; calcified lesions, N = 36) and 32 volunteers from a non-endemic area of Peru. Overall sensitivity of urine antigen detection for viable parasites was 92%, which decreased to 62.5% in patients with a single cyst. Most patients (30/36, 83%) with only calcified cysticercosis were urine antigen negative. Antigen levels in paired serum/urine samples (evaluated in 19 patients) were strongly correlated. Non-invasive urine testing for T. solium antigens provides a useful alternative for NCC diagnosis.
机译：神经囊尾rc病（NCC）是癫痫和癫痫的主要原因。诊断基于大脑成像，并在血清或脑脊液（CSF）中进行免疫诊断。腰穿是侵入性的且痛苦的。血液采样有些痛苦，接受程度也很差。尿液抗原检测已用于其他寄生虫，并在NCC中以次佳的性能进行了尝试。我们使用基于单克隆抗体的ELISA方法检测了87名秘鲁神经囊尾ice病患者（活囊肿，N = 34;蛛网膜下腔囊尾rc病，N = 10;退化性寄生虫，N = 7;钙化病变，N = 36）尿中的Ta虫so抗原。来自秘鲁非疫区的32名志愿者。尿液抗原检测对寄生虫的总体敏感性为92％，在单个囊肿患者中降低至62.5％。大多数仅钙化囊尾rc病的患者（30 / 36，83％）尿液抗原阴性。配对的血清/尿液样本中的抗原水平（在19例患者中评估）密切相关。 T. solium抗原的非侵入性尿液检测为NCC诊断提供了有用的替代方法。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号