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首页> 外文期刊>The American Journal of Tropical Medicine and Hygiene >Dexamethasone Effects in the Strongyloides venezuelensis Infection in A Murine Model.
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Dexamethasone Effects in the Strongyloides venezuelensis Infection in A Murine Model.

机译：地塞米松在小鼠模型中对委内瑞拉氏菌感染的影响。

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Abstract. The aim of this study was to investigate the immunomodulatory effects of glucocorticoids on the immune response to Strongyloides venezuelensis in mice. Balb/c mice were infected with S. venezuelensis and treated with Dexamethasone (Dexa) or vehicle. Dexa treatment increased circulating blood neutrophil numbers and inhibited eosinophil and mononuclear cell accumulation in the blood, bronchoalveolar, and peritoneal fluid compared with control animals. Moreover, Dexa decreased tumor necrosis factor-alpha (TNF-alpha), interferon-gamma (IFN-gamma), interleukin-3 (IL-3), IL-4, IL-5, IL-10, and IL-12 production in the lungs and circulating immunoglobulin G1 (IgG1), IgG2a, and IgE antibody levels while increasing the overall parasite burden in the feces and intestine. Dexa treatment enhanced the fertility of female nematodes relative to untreated and infected mice. In summary, the alterations in the immune response induced by Dexa resulted in a blunted, aberrant immune response associated with increased parasite burden. This phenomenon is similar to that observed in S. stercoralis-infected humans who are taking immunosuppressive or antiinflammatory drugs, including corticosteroids.
机译：抽象。这项研究的目的是研究糖皮质激素对小鼠对委内瑞拉线虫的免疫应答的免疫调节作用。 Balb / c小鼠感染了委内瑞拉链球菌，并用地塞米松（Dexa）或赋形剂处理。与对照动物相比，Dexa治疗可增加循环血中性粒细胞的数量，并抑制血液，支气管肺泡和腹膜液中嗜酸性粒细胞和单核细胞的积累。此外，Dexa降低了肿瘤坏死因子-α（TNF-alpha），干扰素-γ（IFN-γ），白介素-3（IL-3），IL-4，IL-5，IL-10和IL-12的产生。肺和循环免疫球蛋白G1（IgG1），IgG2a和IgE抗体水平升高，同时增加了粪便和肠道中的总体寄生虫负担。相对于未治疗和感染的小鼠，Dexa治疗增强了雌性线虫的繁殖力。总而言之，由Dexa引起的免疫反应的改变导致与寄生虫负担增加相关的钝的，异常的免疫反应。这种现象类似于在接受免疫抑制或抗炎药（包括皮质类固醇）的链球菌感染的人类中观察到的现象。

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