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首页> 外文期刊>The American Journal of Tropical Medicine and Hygiene >Intracytoplasmic hemozoin (malarial pigment) in a case of severe, aparasitemic Plasmodium falciparum malaria.
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Intracytoplasmic hemozoin (malarial pigment) in a case of severe, aparasitemic Plasmodium falciparum malaria.

机译：严重的寄生虫性恶性疟原虫疟疾病例中的胞浆内血腥素（疟疾色素）。

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摘要

A 17-year-old girl from Togo with a beta-thalassemia maior was seen at an emergency department with high fever, coma, and severe anemia (Hb < 3 g/dL). No malaria parasites were found on thin film and thick smears in the first few days of the infection. Despite the failure to observe Plasmodium intraerythro-cytic forms in the bloodstream, many white blood cells showed brown, birefringent, intracytoplasmic inclusions (thick arrows) consistent with malarial pigment (hemozom).The detection of intraleucocytic hemozoin with a negative malaria smear has to be considered as strongly suggestive of Plasmodium fal-ciparum infection1 (Figure 1). Additional blood specimens were analyzed by a pan-human Plasmodium polymerase chain reaction and resulted positives. Further thin films and thick smears were prepared from fingerprick and venipunc-ture the next day, and they showed visible intraerythrocytic rings. The patient was treated with IV quinine and recovered completely.
机译：在多哥的一名17岁女孩患有β地中海贫血，在高烧，昏迷和严重贫血（Hb <3 g / dL）的急诊室被发现。在感染的前几天，在薄膜和厚涂片上未发现疟疾寄生虫。尽管未能观察到血液中的疟原虫内红细胞胞浆形式，但许多白细胞仍显示出棕色，双折射，胞浆内包涵物（粗箭头）与疟疾色素（hemozom）相一致。被认为强烈提示恶性疟原虫感染（图1）。通过全人类疟原虫聚合酶链反应分析了其他血液样本，并得出阳性结果。第二天从手指刺和静脉穿刺制备了进一步的薄膜和较厚的涂片，它们显示出可见的红细胞内环。该患者接受静脉注射奎宁治疗，完全康复。

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