Meloxicam and selective COX-2 inhibitors in the management of pain in the palliative care population.

Smith HS; Baird W

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Meloxicam and selective COX-2 inhibitors in the management of pain in the palliative care population.

机译：美洛昔康和选择性COX-2抑制剂可缓解姑息治疗人群的疼痛。

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This paper discusses the treatment of pain in the palliative care patient, specifically the use of meloxicam and recent advances in agents with cyclooxygenase-2 (COX-2) selectivity. Meloxicam is a nonsteroidal anti-inflammatory drug (NSAID) that preferentially inhibits COX-2 more than cyclooxygenase-1 (COX-1), especially at low doses, thereby offering advantages over traditional nonselective NSAIDs. New COX-2 selective agents are discussed, including valdecoxib, parecoxib, etoricoxib, and COX-189.

机译：本文讨论了姑息治疗患者的疼痛治疗，特别是美洛昔康的使用以及具有环氧合酶2（COX-2）选择性的药物的最新进展。美洛昔康是一种非甾体类抗炎药（NSAID），与环加氧酶-1（COX-1）相比，其抑制COX-2的优先级更高，尤其是在低剂量时，因此具有优于传统非选择性NSAID的优势。讨论了新的COX-2选择性药物，包括伐地考昔，帕瑞昔布，依托昔布和COX-189。

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《The American journal of hospice and palliative care》 |2003年第4期|共10页
作者
Smith HS; Baird W;
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正文语种 eng
中图分类预防医学、卫生学;
关键词
Prostaglandin-Endoperoxide Synthase; meloxicam; Pain; inhibitors; Anti-Inflammatory Agents; Non-Steroidal; 前列腺素内过氧化物合酶; 疼痛; 消炎药; 非甾类;

机译：Prostaglandin-Endoperoxide Synthase;meloxicam;Pain;inhibitors;Anti-Inflammatory Agents;Non-Steroidal;前列腺素内过氧化物合酶;疼痛;消炎药;非甾类;

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1. Meloxicam and selective COX-2 inhibitors in the management of pain in the palliative care population. [J] . Smith HS, Baird W The American journal of hospice and palliative care . 2003,第4期

机译：美洛昔康和选择性COX-2抑制剂可缓解姑息治疗人群的疼痛。
2. The Role of COX-2 in Acute Pain and the Use of Selective COX-2 Inhibitors for Acute Pain Relief. [J] . Lee Y, Rodriguez C, Dionne RA Current pharmaceutical design . 2005,第14期

机译：COX-2在急性疼痛中的作用以及选择性COX-2抑制剂在急性疼痛缓解中的用途。
3. The Role of COX-2 in Acute Pain and the Use of Selective COX-2 Inhibitors for Acute Pain Relief [J] . Y. Lee C. Rodriguez R. A. Dionne Current Pharmaceutical Design . 2005,第14期

机译：COX-2在急性疼痛中的作用以及选择性COX-2抑制剂在急性疼痛缓解中的用途
4. Laminar COX-1 and COX-2 Protein Expression in the Developmental Stage of Laminitis: A Case for Use of COX-2 Selective Inhibitors? [C] . James K. Belknap, Anthony Blikslager, Kimberly Jennings Annual Convention of the American Association of Equine Practitioners . 2004

机译：层层COX-1和COX-2蛋白表达在层层发育阶段：使用COX-2选择性抑制剂的情况？
5. Educating Palliative Care Staff Increases Utilization of Mindfulness Based Cognitive Therapy to Manage Depression in Palliative Care Patients with Chronic Pain [D] . Harper, Christopher Michael. 2019

机译：教育姑息治疗员工增加了令人核心的认知治疗的利用，以管理患有慢性疼痛的姑息治疗患者的抑郁症
6. Meloxicam a Selective COX-2 Inhibitor Mediates Hypoxia-Inducible Factor- (HIF-) 1α Signaling in Hepatocellular Carcinoma [O] . Yinghong Zhou, Xiaofeng Dong, Peng Xiu, 2020

机译：美洛昔康一种选择性的COX-2抑制剂在肝细胞癌中介导缺氧诱导因子-（HIF-）1α信号传导。
7. Comparative population pharmacokinetics and absolute oral bioavailability of COX-2 selective inhibitors celecoxib, mavacoxib and meloxicam in cockatiels (Nymphicus hollandicus) [O] . Dhondt Laura, Devreese Mathias, Croubels Siska, 2017

机译：鹦鹉（Nymphicus hollandicus）中COX-2选择性抑制剂塞来昔布，mavacoxib和美洛昔康的比较群体药代动力学和绝对口服生物利用度

Meloxicam and selective COX-2 inhibitors in the management of pain in the palliative care population.

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