Development of a pH-activatable fluorescent probe and its application for visualizing cellular pH change

Huang R.; Yan S.; Zheng X.; Luo F.; Deng M.; Fu B.; Xiao Y.; Zhao X.; Zhou X.

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Development of a pH-activatable fluorescent probe and its application for visualizing cellular pH change

机译：可pH激活的荧光探针的开发及其在可视化细胞pH变化中的应用

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Novel pH-activatable fluorescent probes with various pK _a values have been developed utilizing 4-nitro-benzo[1,2,5]oxadiazole derivatives (NBD) as fluorophores and piperazine moieties as proton receptors. Under acidic conditions, probe FoPz displayed significant fluorescent enhancement of about 30 fold with a pK _a value of 5.70 and it responds rapidly and sensitively to intracellular pH distributions and cellular pH fluctuations.

机译：利用4-硝基-苯并[1,2,5]恶二唑衍生物（NBD）作为荧光团和哌嗪部分作为质子受体，已开发出具有各种pK _a值的新型pH活化荧光探针。在酸性条件下，探针FoPz显示出约30倍的显着荧光增强，pK _a值为5.70，并且它对细胞内pH分布和细胞pH波动做出快速而敏感的响应。

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《The Analyst: The Analytical Journal of the Royal Society of Chemistry: A Monthly International Publication Dealing with All Branches of Analytical Chemistry》 |2012年第19期|共3页
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Huang R.; Yan S.; Zheng X.; Luo F.; Deng M.; Fu B.; Xiao Y.; Zhao X.; Zhou X.;
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中图分类分析化学;
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1. Development of a pH-activatable fluorescent probe and its application for visualizing cellular pH change [J] . Huang R., Yan S., Zheng X., The Analyst: The Analytical Journal of the Royal Society of Chemistry: A Monthly International Publication Dealing with All Branches of Analytical Chemistry . 2012,第19期

机译：可pH激活的荧光探针的开发及其在可视化细胞pH变化中的应用
2. A colorimetric and ratiometric fluorescent pH probe based on ring opening/closing approach and its applications in monitoring cellular pH change [J] . You Qi-Hua, Lee Yee Man, Chan Wing Hong, RSC Advances . 2015,第6期

机译：基于开环/闭环方法的比色和比例荧光pH探针及其在监测细胞pH变化中的应用
3. pH-activatable near-infra red fluorescent probes for detection of lysosomal pH inside living cells [J] . Giri K. Vegesna, Oagadeesh Janjanam, Jianheng Bi Journal of Materials Chemistry, B. materials for biology and medicine . 2014,第28期

机译：可激活pH值的近红外荧光探针，用于检测活细胞内的溶酶体pH
4. Fluorescent pH probes, Fluorescent Proteins, and Intrinsic Cellular Fluorochromes are Tools to Study Cytosolic pH (pH~(cyt)) in Mammalian Cells [C] . Gloria M. Martinez, Lauren S. Gollahon, Keri Shafer, Society of Photo-Optical Instrumentation Engineers Conference on Biomarkers and Biological Spectral Imaging . 2001

机译：荧光pH探针，荧光蛋白和固有细胞荧光致荧光剂是在哺乳动物细胞中研究细胞溶胶pH（pH〜（cyt））的工具
5. Novel Fluorescent Probes for Visualization of pH Changes and Zn (II) Ions in Live Cells [D] . Fang, Mingxi. 2018

机译：用于可视化pH变化和活细胞中的Zn（II）离子的新型荧光探针
6. Engineering a nanolab for the determination of lysosomal nitric oxide by the rational design of a pH-activatable fluorescent probe [O] . Yinhui Li, Wei Wu, Jinfeng Yang, 2016

机译：通过合理设计可pH激活的荧光探针来设计一个纳米实验室以测定溶酶体一氧化氮
7. A colorimetric and ratiometric fluorescent pH probe based on ring opening/closing approach and its applications in monitoring cellular pH change [O] . Qi-Hua You, Yee Man Lee, Wing Hong Chan, 2015

机译：基于环形开启/关闭方法的比色和比例荧光pH探针及其在监测细胞pH变化中的应用

Development of a pH-activatable fluorescent probe and its application for visualizing cellular pH change

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