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首页> 外文期刊>The British journal of psychiatry : >Neuropsychological functioning in first-episode schizophrenia.
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Neuropsychological functioning in first-episode schizophrenia.

机译：首发精神分裂症的神经心理学功能。

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摘要

BACKGROUND: Identifying neurocognitive subtypes in schizophrenia may help establish neurobiologically meaningful subtypes of the disorder, but is frequently confounded by differences in intellectual function between individuals with schizophrenia and controls. AIMS: To examine neuropsychological performance in individuals with epidemiologically based, first-onset schizophrenia and intellectually matched controls. METHOD: Using standard IQ and reading tests, we examined the proportions of 101 people with epidemiologically derived, first-onset schizophrenia/schizoaffective disorder and 317 community controls, falling into three a priori defined intellectual categories: 'stable good', 'deteriorated poor' and 'stable poor'. Neuropsychological function was compared between intellectually matched participants with schizophrenia and control subgroups. RESULTS: Multiple deficits in executive function, processing speed and verbal memory, but not visual/spatial perception/memory, were detected in all participant groups with schizophrenia compared with controls. The average effect size across the affected domains ranged from small to medium to large in the stable good, deteriorated poor and stable poor subgroups of participants with schizophrenia, respectively. CONCLUSIONS: Compared with intellectually matched controls, people with epidemiologically derived, first-onset schizophrenia/schizoaffective disorder show multiple deficits in executive function, processing speed and verbal memory.
机译：背景：识别精神分裂症中的神经认知亚型可能有助于建立该疾病的神经生物学意义上的亚型，但常因精神分裂症患者与对照组之间的智力功能差异而混淆。目的：研究基于流行病学，首次发作的精神分裂症和智力匹配对照的个体的神经心理学表现。方法：使用标准智商和阅读测试，我们调查了101名流行病学原因，首次发作的精神分裂症/精神分裂症和317名社区控制者的比例，分为三个先验定义的智力类别：“稳定好”，“病情恶化”和“稳定的穷人”。在智力匹配的精神分裂症参与者和对照组之间比较了神经心理功能。结果：与对照组相比，在所有患有精神分裂症的参与者组中均检测到执行功能，处理速度和言语记忆的多个缺陷，但未发现视觉/空间知觉/记忆。在精神分裂症患者的稳定品，恶化的贫困者和稳定的贫困亚组中，受影响区域的平均效应大小从小到中到大。结论：与智力上相匹配的对照相比，患有流行病学上首次发作的精神分裂症/精神分裂症的人表现出执行功能，处理速度和言语记忆方面的多个缺陷。

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