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首页> 外文期刊>The British journal of psychiatry : >Paroxetine in social phobia/social anxiety disorder. Randomised, double-blind, placebo-controlled study. Paroxetine Study Group.
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Paroxetine in social phobia/social anxiety disorder. Randomised, double-blind, placebo-controlled study. Paroxetine Study Group.

机译：帕罗西汀治疗社交恐惧症/社交焦虑症。随机，双盲，安慰剂对照研究。帕罗西汀研究组。

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BACKGROUND: Preliminary studies have suggested that paroxetine may be effective in social phobia/social anxiety disorder. AIMS: To assess the efficacy and tolerability of paroxetine in the acute (12-week) treatment of social phobia. METHOD: Two-hundred and ninety patients with social phobia were assigned randomly to paroxetine (20-50 mg/day flexible dose) or placebo for 12 weeks of double-blind treatment. Primary efficacy outcomes were the Liebowitz Social Anxiety Scale (LSAS) total score (patient-rated) and the Clinical Global Impression (CGI) scale global improvement item. The secondary efficacy variables included CGI scale severity of illness score and the patient-rated Social Avoidance and Distress Scale. RESULTS: Paroxetine produced a significantly greater reduction in LSAS total score (mean change from baseline: -29.4 v. -15.6; P < or = 0.001) and a greater proportion of responders (score < or = 2 on CGI global improvement) (65.7% v. 32.4%; P < 0.001) compared with placebo at the end of the 12-week study period. Both primary efficacy variables were statistically significant compared with placebo from week 4 onwards. Paroxetine was generally well tolerated. CONCLUSIONS: Paroxetine is an effective, well-tolerated treatment for patients with social phobia.
机译：背景：初步研究表明，帕罗西汀在社交恐惧症/社交焦虑症中可能有效。目的：评估帕罗西汀在急性（12周）社交恐惧症治疗中的疗效和耐受性。方法：将290例社交恐惧症患者随机分配至帕罗西汀（20-50 mg /日，灵活剂量）或安慰剂，进行12周的双盲治疗。主要疗效指标为利勃维茨社交焦虑量表（LSAS）总分（患者评分）和临床总体印象（CGI）量表总体改善项目。次要疗效变量包括CGI量表的疾病严重程度评分和患者评分的社会回避和困扰量表。结果：帕罗西汀在LSAS总得分上的降低幅度更大（相对于基线的平均变化：-29.4对-15.6; P <或= 0.001），应答者的比例也更大（CGI总体改善得分＜或= 2）（65.7在12周研究期结束时，与安慰剂比较的结果为：％vs. 32.4％; P <0.001）。从第4周开始，与安慰剂相比，这两个主要功效变量在统计学上均具有统计学意义。帕罗西汀通常耐受良好。结论：帕罗西汀对社交恐怖症患者是一种有效且耐受良好的治疗方法。

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