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首页> 外文期刊>The British journal of psychiatry : >Premorbid functioning and treatment response in recent-onset schizophrenia.
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Premorbid functioning and treatment response in recent-onset schizophrenia.

机译：最近发作的精神分裂症的病前功能和治疗反应。

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BACKGROUND: Investigating the relationship between premorbid functioning and treatment response in schizophrenia is relevant to understanding the illness and predicting treatment outcomes. AIMS: To examine the relationship between premorbid characteristics and treatment response of people with recent-onset schizophrenia. METHOD: Data came from a large, double-blind trial of recent-onset psychosis treated with a flexible dose of risperidone or haloperidol. Median treatment length was 206 days. Premorbid functioning was categorised using the Cannon-Spoor Premorbid Adjustment Scale. RESULTS: There were significant differences between the premorbid groups on change on the Positive and Negative Syndrome Scale, Clinical Global Impression severity and cognitive functioning and Extrapyramidal Symptoms Rating Scale. Patients in the ;stable-good' premorbid group (n = 251) improved more than those in the'stable-poor' (n = 198) and 'declining' (n = 81) groups. The ;stable-good' group received the lowest doses of antipsychotic and had the least extrapyramidal symptoms. Patients in the 'declining' group had the highest dosages and the most extrapyramidal symptoms. CONCLUSIONS: In first-episode psychosis good premorbid functioning is associated with better response to treatment and fewer extrapyramidal symptoms.
机译：背景：研究精神分裂症病前功能与治疗反应之间的关系与了解疾病和预测治疗结果有关。目的：探讨近期发作的精神分裂症患者的病前特征与治疗反应之间的关系。方法：数据来自一项大型的双盲试验，该试验采用弹性剂量的利培酮或氟哌啶醇治疗新近发作的精神病。中位治疗时间为206天。使用Cannon-Spoor病前调整量表对病前功能进行分类。结果：病前组在阳性和阴性综合征量表，临床总体印象严重程度以及认知功能和锥体外系症状评定量表上的变化之间存在显着差异。 “稳定好”病前组（n = 251）的患者比“稳定差”（n = 198）和“下降”（n = 81）组的患者改善更多。 “稳定-良好”组的抗精神病药剂量最低，而锥体外系症状最少。 “下降”组的患者剂量最高，锥体外系症状最多。结论：在首发性精神病中，良好的病前功能与对治疗的较好反应和较少的锥体外系症状有关。

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