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首页> 外文期刊>The British journal of psychiatry : >Pharmacological treatment for unipolar psychotic depression: Systematic review and meta-analysis.
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Pharmacological treatment for unipolar psychotic depression: Systematic review and meta-analysis.

机译：单相性精神病性抑郁症的药物治疗：系统评价和荟萃分析。

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BACKGROUND: The optimal pharmacological treatment of unipolar psychotic depression is uncertain. AIMS: To compare the clinical effectiveness of pharmacological treatments for patients with unipolar psychotic depression. METHOD: Systematic review and meta-analysis of randomised controlled trials. RESULTS: Ten trials were included in the review. We found no evidence that the combination of an antidepressant with an antipsychotic is more effective than an antidepressant alone.This combination was statistically more effective than an antipsychotic alone. CONCLUSIONS: Antidepressant monotherapy and adding an antipsychotic if the patient does not respond, or starting with the combination of an antidepressant and an antipsychotic, both appear to be appropriate options for patients with unipolar psychotic depression.However, clinically the balance between risks and benefits may suggest the first option should be preferred for many patients. Starting with an antipsychotic alone appears to be inadequate.
机译：背景：单相精神病性抑郁症的最佳药理治疗尚不确定。目的：比较药物治疗对单相精神病性抑郁症患者的临床效果。方法：对随机对照试验进行系统评价和荟萃分析。结果：十项试验包括在评价中。我们发现没有证据表明抗抑郁药与抗精神病药联合使用比单独使用抗抑郁药更有效，而该组合在统计学上比单独使用抗精神病药更有效。结论：抗抑郁药单药治疗，如果患者无反应则加抗精神病药，或从抗抑郁药和抗精神病药的组合开始，似乎都是单相精神病性抑郁症患者的适当选择，但临床上风险与收益之间的平衡可能建议许多患者应首选第一选择。仅以抗精神病药开始似乎是不够的。

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