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首页> 外文期刊>The British journal of psychiatry : >Psychosis and autism: magnetic resonance imaging study of brain anatomy.
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Psychosis and autism: magnetic resonance imaging study of brain anatomy.

机译：精神病和自闭症：脑解剖结构的磁共振成像研究。

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BACKGROUND: Autism-spectrum disorder is increasingly recognised, with recent studies estimating that 1% of children in South London are affected. However, the biology of comorbid mental health problems in people with autism-spectrum disorder is poorly understood. AIMS: To investigate the brain anatomy of people with autism-spectrum disorder with and without psychosis. METHOD: We used in vivo magnetic resonance imaging and compared 30 adults with autism-spectrum disorder (14 with a history psychosis) and 16 healthy controls. RESULTS: Compared with controls both autism-spectrum disorder groups had significantly less grey matter bilaterally in the temporal lobes and the cerebellum. In contrast, they had increased grey matter in striatal regions. However, those with psychosis also had a significant reduction in grey matter content of frontal and occipital regions. Contrary to our expectation, within autism-spectrum disorder, comparisons revealed that psychosis was associated with a reduction in grey matter of the right insular cortex and bilaterally in the cerebellum extending into the fusiform gyrus and the lingual gyrus. CONCLUSIONS: The presence of neurodevelopmental abnormalities normally associated with autism-spectrum disorder might represent an alternative 'entry-point' into a final common pathway of psychosis.
机译：背景：自闭症谱系障碍已得到越来越多的认识，最近的研究估计，南伦敦有1％的儿童受到影响。但是，对自闭症谱系障碍患者共病心理健康问题的生物学了解甚少。目的：调查患有和不患有精神病的自闭症谱系障碍患者的大脑解剖结构。方法：我们使用体内磁共振成像技术，对30例自闭症谱系障碍成年人（14例有精神病史）和16例健康对照者进行了比较。结果：与对照组相比，自闭症谱系障碍组在颞叶和小脑两侧的灰质明显减少。相反，它们在纹状体区域增加了灰质。但是，患有精神病的人的额叶和枕叶区域的灰质含量也显着降低。与我们的预期相反，在自闭症谱系障碍中，比较显示精神病与右岛状皮层和双侧小脑的灰质减少有关，小脑两侧延伸到梭形回和舌状回。结论：通常与自闭症谱系障碍有关的神经发育异常的存在可能代表了进入精神病的最终常见途径的另一种“切入点”。

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