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首页> 外文期刊>The British journal of psychiatry : >Shared polygenic contribution between childhood attention-deficit hyperactivity disorder and adult schizophrenia
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Shared polygenic contribution between childhood attention-deficit hyperactivity disorder and adult schizophrenia

机译：儿童注意缺陷多动障碍与成人精神分裂症之间的多基因贡献

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Background: There is recent evidence of some degree of shared genetic susceptibility between adult schizophrenia and childhood attention-deficit hyperactivity disorder (ADHD) for rare chromosomal variants. Aims: To determine whether there is overlap between common alleles conferring risk of schizophrenia in adults with those that do so for ADHD in children. Method: We used recently published Psychiatric Genome-wide Association Study (GWAS) Consortium (PGC) adult schizophrenia data to define alleles over-represented in people with schizophrenia and tested whether those alleles were more common in 727 children with ADHD than in 2067 controls. Results: Schizophrenia risk alleles discriminated ADHD cases from controls (P = 1.04×10-4, R 2 = 0.45%); stronger discrimination was given by alleles that were risk alleles for both adult schizophrenia and adult bipolar disorder (also derived from a PGC data-set) (P = 9.98×10-6, R2 = 0.59%). Conclusions: This increasing evidence for a small, but significant, shared genetic susceptibility between adult schizophrenia and childhood ADHD highlights the importance of research work across traditional diagnostic boundaries.
机译：背景：最近有证据表明，成人精神分裂症和儿童注意力缺乏亢进症（ADHD）对罕见的染色体变异有一定程度的共同遗传易感性。目的：确定在成年人中常见的等位基因与在儿童中患有多动症的等位基因之间是否存在重叠。方法：我们使用最近发表的《精神病学全基因组关联研究（GWAS）联合会（PGC）成人精神分裂症数据》来定义精神分裂症患者中过度代表的等位基因，并测试这些等位基因是否在727名ADHD儿童中比在2067名对照中更为常见。结果：精神分裂症的风险等位基因将ADHD病例与对照组相区别（P = 1.04×10-4，R 2 = 0.45％）;成年精神分裂症和成年双相情感障碍的风险等位基因的等位基因（也来自PGC数据集）具有较强的区分力（P = 9.98×10-6，R2 = 0.59％）。结论：这种增加的证据表明，成人精神分裂症与儿童多动症之间存在很小但重要的共同遗传易感性，这突显了跨越传统诊断界限进行研究工作的重要性。

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