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首页> 外文期刊>The European Journal of Neuroscience >Preconditioning selective ventral root injury promotes plasticity of ascending sensory neurons in the injured spinal cord of adult rats--possible roles of brain-derived neurotrophic factor, TrkB and p75 neurotrophin receptor.
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Preconditioning selective ventral root injury promotes plasticity of ascending sensory neurons in the injured spinal cord of adult rats--possible roles of brain-derived neurotrophic factor, TrkB and p75 neurotrophin receptor.

机译：预处理选择性腹侧根损伤可促进成年大鼠脊髓损伤中上行感觉神经元的可塑性-脑源性神经营养因子，TrkB和p75神经营养因子受体的可能作用。

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摘要

Preconditioning sciatic nerve injury enhances axonal regeneration of ascending sensory neurons after spinal cord injury. A key question is whether direct injury of sensory nerves is necessary for the enhanced regeneration. The lumbar 5 ventral root transection (L5 VRT) model, a model of selective motor nerve injury, provides a useful tool to address this question. Here we examined the effects of a preconditioning L5 VRT on the regeneration after a subsequent dorsal column transection (DCT) in adult Sprague-Dawley rats. We found that L5 VRT 1 week before DCT increased the number of Fast Blue (FB)-labeled neurons in the L5 dorsal root ganglia (DRG) and promoted sprouting/regenerating axons to grow into the glial scar. L5 VRT also induced a dramatic upregulation of expression of brain-derived neurotrophic factor (BDNF) in the preconditioned DRG and in the injured spinal cord. Moreover, almost all of the FB-labeled sprouting/regenerating neurons expressed BDNF, and approximately 55% of these neurons were surrounded by p75 neurotrophin receptor-positive glial cells. This combined injury led to an increase in the number of BDNF- and TrkB-immunoreactive nerve fibers in the dorsal column caudal to the lesion site. Taken together, these findings demonstrate that L5 VRT promotes sprouting/regeneration of ascending sensory neurons, indicating that sensory axotomy may not be essential for the plasticity of injured dorsal column axons. Thus, the sensory neurons could be preprimed in the regenerative milieu of Wallerian degeneration and neuroinflammation, which might alter the expression of neurotrophic factors and their receptors, facilitating sprouting/regeneration of ascending sensory neurons.
机译：预处理坐骨神经损伤可增强脊髓损伤后上行感觉神经元的轴突再生。一个关键的问题是，是否需要直接伤害感觉神经来增强再生。腰5腹根横切（L5 VRT）模型是选择性运动神经损伤的模型，为解决该问题提供了有用的工具。在这里，我们研究了成年的Sprague-Dawley大鼠在进行背柱横断（DCT）后，预处理L5 VRT对再生的影响。我们发现，DCT前1周的L5 VRT增加了L5背根神经节（DRG）中的鲜蓝色（FB）标记的神经元数量，并促进了发芽/再生轴突生长为神经胶质瘢痕。 L5 VRT还可在预处理的DRG和受伤的脊髓中诱导脑源性神经营养因子（BDNF）表达的急剧上调。此外，几乎所有FB标记的发芽/再生神经元都表达BDNF，并且这些神经元中约有55％被p75神经营养素受体阳性神经胶质细胞包围。这种合并的损伤导致位于病变部位尾侧的背柱中的BDNF和TrkB免疫反应性神经纤维的数量增加。综上所述，这些发现表明L5 VRT促进了上行感觉神经元的发芽/再生，表明感觉轴突切开术对于受伤的背柱轴突的可塑性可能不是必不可少的。因此，感觉神经元可能在Wallerian变性和神经发炎的再生环境中被引发，这可能会改变神经营养因子及其受体的表达，从而促进上升的感觉神经元的萌芽/再生。

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