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首页> 外文期刊>The European Journal of Neuroscience >Chemical communication between regenerating motor axons and Schwann cells in the growth pathway.
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Chemical communication between regenerating motor axons and Schwann cells in the growth pathway.

机译：生长通路中再生运动轴突和雪旺细胞之间的化学通讯。

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摘要

There are receptors on denervated Schwann cells that may respond to the neurotransmitters that are released from growth cones of regenerating motor axons. In order to ascertain whether the interaction of the transmitters and their receptors plays a role during axon regeneration, we investigated whether pharmacological block of the interaction would reduce the number of motoneurons that regenerate their axons after nerve section and surgical repair. Peripheral nerves in the hindlimbs of rats and mice were cut and repaired, and various drugs were applied to the peripheral nerve stump either directly or via mini-osmotic pumps over a 2-4-week period to block the binding of acetylcholine to nicotinic and muscarinic acetylcholine receptors (AChRs: alpha-bungarotoxin, tubocurarine, atropine and, gallamine) and binding of ATP to P2Y receptors (suramin). In rats, the nicotinic AChR antagonistic drugs and suramin reduced the number of motoneurons that regenerated their axons through the distal nerve stump. In mice, suramin significantly reduced the upregulation of the carbohydrate HNK-1 on the Schwann cells in the distal nerve stump that normally occurs during motor axon regeneration. These data indicate that chemical communication between regenerating axons and Schwann cells during axon regeneration via released neurotransmitters and their receptors may play an important role in axon regeneration.
机译：去神经化的雪旺氏细胞上有一些受体可能对从再生运动轴突的生长锥中释放的神经递质作出反应。为了确定递质及其受体的相互作用在轴突再生过程中是否起作用，我们调查了相互作用的药理作用是否会减少神经节和手术修复后再生其轴突的运动神经元的数量。切除并修复了大鼠和小鼠后肢的周围神经，并在2-4周内直接或通过微型渗透泵将各种药物应用于周围神经残端，以阻止乙酰胆碱与烟碱和毒蕈碱结合乙酰胆碱受体（AChR：α-真菌毒素，微管尿素，阿托品和没食子胺）以及ATP与P2Y受体的结合（苏拉明）。在大鼠中，烟碱型AChR拮抗药和苏拉明减少了通过远端神经残端再生其轴突的运动神经元的数量。在小鼠中，苏拉明可显着减少正常运动轴突再生过程中远端神经残端雪旺细胞中碳水化合物HNK-1的上调。这些数据表明，在轴突再生过程中，通过释放的神经递质及其受体，再生轴突与雪旺细胞之间的化学通讯可能在轴突再生中起重要作用。

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