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首页> 外文期刊>The European Journal of Neuroscience >Effects of thyroid hormone replacement on associative learning and hippocampal synaptic plasticity in adult hypothyroid rats.
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Effects of thyroid hormone replacement on associative learning and hippocampal synaptic plasticity in adult hypothyroid rats.

机译：甲状腺激素替代对成年甲状腺功能减退大鼠联想学习和海马突触可塑性的影响。

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Activity-dependent changes taking place at the hippocampal perforant pathway-dentate gyrus synapse during classical eyeblink conditioning were recorded in adult thyroidectomized (hypothyroid) and control (euthyroid) rats, and in animals treated with thyroid hormones 20 days after thyroidectomy (recovery rats). The aim was to determine the contribution of thyroid hormones and the consequences of adult-onset hypothyroidism to both associative learning and the physiological potentiation of hippocampal synapses during the actual learning process in alert behaving animals. Control and recovery rats presented similar learning curves, whereas hypothyroid animals presented lower values. A single pulse presented to the perforant pathway during the conditioned-unconditioned inter-stimulus interval evoked a monosynaptic field excitatory postsynaptic potential in dentate granule cells (whose slope was linearly related to the rate of acquisition in the control group), but not in hypothyroid and recovery animals. Input-output relationships and long-term potentiation evoked by train stimulation of the perforant pathway were significantly depressed in hypothyroid animals. Thyroid hormone treatment failed to normalize these two neurophysiological abnormalities observed in hypothyroid animals. In contrast, paired-pulse facilitation was not affected by thyroidectomy. The results indicate that thyroid hormone treatment after a short period of adult hypothyroidism helps to restore some hippocampally dependent functions, such as classical conditioning, but not other hippocampal properties, such as the synaptic plasticity evoked during associative learning and during experimentally induced long-term potentiation. The present results have important clinical implications for the handling of patients with adult-onset thyroid diseases.
机译：在成年的甲状腺切除组（甲状腺功能减退）和对照组（甲状腺功能正常）大鼠，以及在甲状腺切除术后20天接受甲状腺激素治疗的动物（恢复大鼠）中，记录了经典的眨眼调节过程中海马穿孔途径-齿状回突触发生的活动依赖性变化。目的是确定机敏行为动物在实际学习过程中甲状腺激素的贡献以及成年甲状腺功能减退症对联想学习和海马突触生理增强的影响。对照和恢复大鼠表现出相似的学习曲线，而甲状腺功能减退的动物表现出较低的值。在条件-非条件间刺激间隔期间，在穿孔通路上出现的单个脉冲在齿状颗粒细胞中引起单突触场兴奋性突触后电位（其斜率与对照组的获得率呈线性相关），但在甲状腺功能减退和恢复动物。在甲状腺功能减退的动物中，通过穿孔路径的火车刺激引起的输入-输出关系和长期增强作用显着降低。甲状腺激素治疗未能使甲状腺功能减退动物中观察到的这两种神经生理异常正常化。相反，成对脉冲的促进不受甲状腺切除术的影响。结果表明，成人甲状腺功能低下症短期治疗后的甲状腺激素治疗有助于恢复某些海马依赖性功能，例如经典条件，但不能恢复其他海马性质，例如在联想学习和实验诱导的长期增强过程中引起的突触可塑性。目前的结果对成人甲状腺疾病患者的处理具有重要的临床意义。

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