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首页> 外文期刊>The European Journal of Neuroscience >Effects of selective thalamic and prelimbic cortex lesions on two types of visual discrimination and reversal learning.
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Effects of selective thalamic and prelimbic cortex lesions on two types of visual discrimination and reversal learning.

机译：选择性丘脑和前缘皮层病变对两种类型的视觉辨别和逆向学习的影响。

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摘要

The effects of excitotoxic lesions of the mediodorsal nucleus of the thalamus, the anterior thalamic nuclei and of the prelimbic cortex were examined on two tests of discrimination and reversal learning. In experiment 1A (visual discrimination and reversal), rats were required to discriminate two stimuli, and respond to the stimulus associated with reward (the S+ stimulus). There was no effect of lesion on acquisition of this task. However, when stimulus-reward contingencies were reversed, animals with lesions of the mediodorsal nucleus of the thalamus made significantly more errors than control animals or animals of other lesion groups. In experiment 1B (conditional discrimination), animals were required to learn a rule of the type 'If stimulus A then go left, if stimulus B then go right'. No main effect of lesion on acquisition was observed in this experiment. To test the generality of the reversal effect obtained in experiment 1A, a second cohort of animals with the same lesions was tested on acquisition of the visuospatial conditional task immediately postsurgery, followed by the reversal of the conditional rule (experiment 2). As in experiment 1B, no main effect of lesion group was observed during acquisition of the task. However, lesions of the mediodorsal nucleus of the thalamus resulted in a mild impairment according to number of sessions required to attain criterion performance of the task when the response rule was reversed. The results of the present study provide evidence for a role for the mediodorsal nucleus of the thalamus in new learning, particularly when stimulus-reward contingencies are reversed. Furthermore, they show that the functions of this thalamic nucleus can be dissociated from those of the anterior thalamus and the prelimbic cortex.
机译：在鉴别和逆向学习的两个测试中检查了丘脑的中嗅核，丘脑前核和前缘皮层的兴奋性毒性损伤的作用。在实验1A（视觉辨别和逆转）中，要求大鼠区分两种刺激，并对与奖赏相关的刺激（S +刺激）作出反应。病变对完成这项任务没有影响。但是，当冲销奖励意外发生时，与丘脑中枢神经核损伤的动物相比，对照动物或其他损伤组的动物犯下的错误要多得多。在实验1B（有条件的歧视）中，要求动物学习“如果刺激A然后向左走，如果刺激B然后向右走”类型的规则。在该实验中未观察到病变对获取的主要影响。为了测试在实验1A中获得的逆转效果的普遍性，在手术后立即采集了视觉空间条件任务，然后逆转了条件规则，对第二组具有相同病变的动物进行了测试（实验2）。与实验1B一样，在完成任务期间未观察到病变组的主要作用。但是，根据响应规则相反时达到任务标准执行要求的疗程数，丘脑的中嗅核损伤会导致轻度损伤。本研究的结果为丘脑的中嗅核在新的学习中发挥作用提供了证据，特别是当刺激奖励意外情况发生逆转时。此外，他们表明，该丘脑核的功能可以与丘脑前部和前丘脑皮层的功能分离。

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