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首页> 外文期刊>The European Journal of Neuroscience >Dendritic excitability during increased synaptic activity in rat neocortical L5 pyramidal neurons.
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Dendritic excitability during increased synaptic activity in rat neocortical L5 pyramidal neurons.

机译：大鼠新皮层L5锥体神经元突触活动增加期间的树突状兴奋性。

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摘要

Recent years have seen increased study of dendritic integration, mostly in acute brain slices. However, due to the low background activity in brain slices the integration of synaptic input in slice preparations may not truly reflect conditions in vivo. To investigate dendritic integration, back-propagation of the action potential (AP) and initiation of the dendritic Ca(2+) spike we simultaneously recorded membrane potential at the soma and apical dendrite of layer 5 (L5) pyramidal neurons in quiescent and excited acute brain slices. After excitation of the brain slice the somatic input resistance decreased and the apparent passive space constant shortened. However, the back-propagating AP and dendritic Ca(2+) spike were robust during increased synaptic activity. The dendritic Ca(2+) spike was suppressed by the ionic composition of the bath solution required for slice excitation, suggesting that Ca(2+) spikes may be smaller in vivo than in the acute slice preparation. The results presented here suggest that, under the conditions of slice excitation examined in this study, the increased membrane conductance induced by activation of voltage-gated channels during back-propagation of the AP and dendritic Ca(2+) spike initiation is sufficiently larger than the membrane conductance at subthreshold potentials to allow these two regenerative dendritic events to remain robust over several levels of synaptic activity in the apical dendrite of L5 pyramidal neurons.
机译：近年来，有关树突整合的研究越来越多，主要是在急性脑切片中。但是，由于脑切片的背景活性较低，因此切片制剂中突触输入的整合可能无法真正反映体内状况。若要调查树突整合，动作电位（AP）的反向传播和树突状Ca（2+）尖峰的启动，我们同时记录了静态和兴奋性急性第5层（L5）锥体神经元的体细胞和顶端树突的膜电位脑片。激发大脑切片后，体细胞输入阻力降低，视在被动空间常数缩短。但是，反向传播的AP和树突状Ca（2+）尖峰在增加的突触活动过程中是强大的。树突状Ca（2+）尖峰被切片激发所需的浴液的离子组成所抑制，表明Ca（2+）尖峰在体内可能比急性切片制备的小。此处显示的结果表明，在本研究中研究的切片激励条件下，AP反向传播和树突状Ca（2+）尖峰引发过程中，电压门控通道的激活所诱导的膜电导增加得比在亚阈值电势下的膜电导，使这两个再生树突事件在L5锥体神经元的顶端树突的几个突触活动水平上均保持稳定。

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