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首页> 外文期刊>The European Journal of Neuroscience >Cannabinoid receptor type 1 receptors on GABAergic vs. glutamatergic neurons differentially gate sex-dependent social interest in mice
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Cannabinoid receptor type 1 receptors on GABAergic vs. glutamatergic neurons differentially gate sex-dependent social interest in mice

机译：GABA能和谷氨酸能神经元上的大麻素受体1型受体差异性地影响了小鼠的性别依赖性社会兴趣

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摘要

Abnormalities in social behavior are found in almost all psychiatric disorders, such as anxiety, depression, autism, and schizophrenia. Thus, comprehension of the neurobiological basis of social interaction is important for a better understanding of numerous pathologies and improved treatments. Several findings have suggested that an alteration of cannabinoid receptor type 1 (CB1) receptor function could be involved in the pathophysiology of such disorders. However, the role of CB1 receptors is still unclear, and their localisation on different neuronal subpopulations may produce distinct outcomes. To dissect the role of CB1 receptors in different neuronal populations, we used male knockout mice and their respective control littermates [total deletion (CB1-/-); specific deletion on cortical glutamatergic neurons (Glu-CB1-/-) or on GABAergic interneurons (GABA-CB1-/-), and wild-type (WT) mice treated with the CB1 antagonist/inverse agonist SR141716A (3 mg/kg). Mice were required to perform different social tasks - direct social interaction and social investigation. Direct interaction of two male mice was not modified in any group; however, when they were paired with females, Glu-CB1-/- mice showed reduced interaction. Also, exploration of the male stimulus subject in the three-chamber social investigation test was almost unaffected. The situation was completely different when a female was used as the stimulus subject. In this case, Glu-CB1-/- mice showed reduced interest in the social stimulus, mimicking the phenotype of CB1-/- or WT mice treated with SR141716A. GABA-CB1-/- mice showed the opposite phenotype, by spending more time investigating the social stimulus. In conclusion, we provide evidence that CB1 receptors specifically modulate the social investigation of female mice in a neuronal subtype-specific manner.
机译：几乎所有精神病患者都会发现社交行为异常，例如焦虑症，抑郁症，自闭症和精神分裂症。因此，理解社会交往的神经生物学基础对于更好地了解多种病理和改善治疗方法很重要。一些发现表明，大麻素1型受体（CB1）受体功能的改变可能与此类疾病的病理生理有关。但是，CB1受体的作用仍不清楚，它们在不同神经元亚群上的定位可能会产生不同的结果。为了剖析CB1受体在不同神经元群体中的作用，我们使用了雄性基因敲除小鼠及其各自的对照同窝仔[总缺失（CB1-/-）;用CB1拮抗剂/反向激动剂SR141716A（3 mg / kg）治疗的皮质谷氨酸能神经元（Glu-CB1-/-）或GABA能神经元（GABA-CB1-/-）和野生型（WT）小鼠的特定缺失。小鼠被要求执行不同的社会任务-直接的社会互动和社会调查。两组雄性小鼠的直接相互作用均未改变。但是，当它们与雌性配对时，Glu-CB1-/-小鼠显示出降低的相互作用。同样，在三腔社会调查中对男性刺激对象的探索几乎不受影响。当女性被用作刺激对象时，情况完全不同。在这种情况下，Glu-CB1-/-小鼠对社交刺激的兴趣降低，模仿了用SR141716A治疗的CB1-/-或WT小鼠的表型。通过花费更多时间研究社会刺激，GABA-CB1-/-小鼠表现出相反的表型。总之，我们提供的证据表明CB1受体以神经元亚型特异性方式特异性调节雌性小鼠的社会调查。

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