...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The European Journal of Neuroscience >Retinal ganglion cells projecting to the accessory optic system in optokinetic blind albinotic rats are direction-selective
【24h】

Retinal ganglion cells projecting to the accessory optic system in optokinetic blind albinotic rats are direction-selective

机译：视神经盲白化病大鼠中投射到副视神经系统的视网膜神经节细胞是方向选择性的

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The optokinetic deficits in albinotic rats and ferrets are caused by the loss of direction selectivity in the accessory optic system (AOS). However, the underlying mechanisms for this loss are still not clear. Here we tested the hypothesis that, in albino rats, the retinal input to the AOS lacks direction selectivity and, as a consequence, neurons in the AOS are direction non-selective. We investigated ON-center direction-selective retinal ganglion cells, the major input to the AOS, in pigmented Long Evans and albino Wistar rats using extracellular in vitro patch-clamp techniques. To visualise putative AOS-projecting direction-selective ganglion cells, we retrogradely labeled them by injection of the infrared-sensitive dye indocyanine green into the medial terminal nucleus of the AOS. The present study is the first to present physiological evidence for retinal ON-center direction-selective ganglion cells in rat. Our results show that, in albinotic and pigmented rats, ON-center retinal ganglion cells projecting to the AOS are similarly direction-selective, suggesting that the optokinetic deficit must be caused by the abolition of direction selectivity in the AOS itself.
机译：白化病大鼠和雪貂的视动学缺陷是由辅助视神经系统（AOS）方向选择性的丧失引起的。但是，这种损失的潜在机制仍不清楚。在这里，我们测试了以下假设：在白化病大鼠中，AOS的视网膜输入缺乏方向选择性，因此，AOS中的神经元是非方向性选择性的。我们使用细胞外体外膜片钳技术研究了色素沉着的长Evans和白化Wistar大鼠的ON-OS方向选择性视网膜神经节细胞，这是AOS的主要输入。为了可视化推定的AOS投影方向选择性神经节细胞，我们通过将红外敏感染料吲哚菁绿注入AOS的内侧末端核来逆向标记它们。本研究是第一个提出大鼠视网膜ON中心方向选择性神经节细胞的生理学证据。我们的结果表明，在白化病和色素沉着的大鼠中，投射到AOS的ON中心视网膜神经节细胞具有类似的方向选择性，这表明光动力学缺陷必须由AOS本身方向选择的取消引起。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号