...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The European Journal of Neuroscience >Primary and secondary somatosensory cortex responses to anticipation and pain: a magnetoencephalography study.
【24h】

Primary and secondary somatosensory cortex responses to anticipation and pain: a magnetoencephalography study.

机译：初级和次级躯体感觉皮层对预期和疼痛的反应：磁脑图研究。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Several brain regions, including the primary and secondary somatosensory cortices (SI and SII, respectively), are functionally active during the pain experience. Both of these regions are thought to be involved in the sensory-discriminative processing of pain and recent evidence suggests that SI in particular may also be involved in more affective processing. In this study we used MEG to investigate the hypothesis that frequency-specific oscillatory activity may be differentially associated with the sensory and affective components of pain. In eight healthy participants (four male), MEG was recorded during a visceral pain experiment comprising baseline, anticipation, pain and post-pain phases. Pain was delivered via intraluminal oesophageal balloon distension (four stimuli at 1 Hz). Significant bilateral but asymmetrical changes in neural activity occurred in the beta-band within SI and SII. In SI, a continuous increase in neural activity occurred during the anticipation phase (20-30 Hz), which continued during the pain phase but at a lower frequency (10-15 Hz). In SII, oscillatory changes only occurred during the pain phase, predominantly in the 20-30 Hz beta band, and were coincident with the stimulus. These data provide novel evidence of functional diversity within SI, indicating a role in attentional and sensory aspects of pain processing. In SII, oscillatory changes were predominantly stimulus-related, indicating a role in encoding the characteristics of the stimulus. We therefore provide objective evidence of functional heterogeneity within SI and functional segregation between SI and SII, and suggest that the temporal and frequency dynamics within cortical regions may offer valuable insights into pain processing.
机译：在疼痛经历期间，几个大脑区域，包括主要和次要的体感皮质（分别为SI和SII）在功能上活跃。人们认为这两个区域都与疼痛的感觉辨别性处理有关，最近的证据表明，特别是SI也可能与更情感的处理有关。在这项研究中，我们使用MEG来研究以下假设：特定频率的振荡活动可能与疼痛的感觉和情感成分有差异。在八名健康参与者（四名男性）中，在内脏疼痛实验期间记录了MEG，包括基线，预期，疼痛和疼痛后阶段。通过腔内食管球囊扩张（1 Hz处的四个刺激）传递疼痛。在SI和SII的β带中，神经活动发生了明显的双边但不对称的变化。在SI中，神经活动在预期阶段（20-30 Hz）期间持续增加，在疼痛阶段持续，但频率较低（10-15 Hz）。在SII中，振荡变化仅在疼痛阶段发生，主要发生在20-30 Hzβ波段，并且与刺激同时发生。这些数据提供了SI内部功能多样性的新证据，表明在疼痛处理的注意力和感觉方面起着作用。在SII中，振荡变化主要与刺激有关，表明在编码刺激特征中起作用。因此，我们提供了SI内部功能异质性以及SI与SII之间功能隔离的客观证据，并建议皮质区域内的时间和频率动态可能为疼痛处理提供有价值的见解。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号