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首页> 外文期刊>The European Journal of Neuroscience >Hemispheric differences in basilar dendrites and spines of pyramidal neurons in the rat prelimbic cortex: activity- and stress-induced changes.
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Hemispheric differences in basilar dendrites and spines of pyramidal neurons in the rat prelimbic cortex: activity- and stress-induced changes.

机译：大鼠前肢皮质中基底树突和锥体神经元棘的半球差异：活动和应激诱导的变化。

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摘要

Pyramidal neurons of the rat medial prefrontal cortex have been shown to react to chronic stress by retracting their apical dendrites and by spine loss. We extended these findings by focusing on the basilar dendritic tree of layer III pyramidal neurons in both hemispheres of the rat prelimbic cortex. Animals were subjected to daily restraint stress for 1 week (6 h/day), during either the resting or the activity period. The morphology of basilar dendrites and spines of Golgi-Cox-stained neurons in the left and right hemispheres was digitally reconstructed and analyzed. We observed the following: (i) there was an inherent hemispheric asymmetry in control rats during the resting period: the number of spines on proximal dendrites was higher in the left than in the right hemisphere; (ii) basal dendrites in controls displayed a diurnal variation: there was more dendritic material during the resting period than in the activity period; (iii) chronic stress reduced the length of basal dendrites in only the right prelimbic cortex; (iv) chronic stress reduced spine density on proximal basal dendrites; (v) restraint stress during the activity period had more pronounced effects on the physiological stress parameters than restraint stress during the resting period. Our results show dynamic hemisphere-dependent structural changes in pyramidal neurons of the rat prelimbic cortex that are tightly linked to periods of resting and activity. These morphological alterations reflect the capacity of the neurons to react to external stimuli and mirror presumptive changes in neuronal communication.
机译：已显示大鼠内侧前额叶皮层的锥体神经元通过收缩其顶端树突和脊柱缺失而对慢性应激作出反应。我们通过集中于大鼠前肢皮层的两个半球中的第三层锥体神经元的基底树突树扩展了这些发现。在休息或活动期间，每天对动物施加1周（6小时/天）的束缚压力。数字化地重建和分析了左右半球中高尔基-科克斯染色的神经元的基底树突和棘的形态。我们观察到以下情况：（i）在休息期间，对照组大鼠存在固有的半球不对称性：左半侧树突状棘突的数量高于右半球; （ii）对照组的基础树突呈昼夜变化：静息期树突状物质多于活动期; （iii）慢性应激仅减少了右前肢皮质的基底树突的长度; （iv）慢性压力降低了近端基底树突的脊柱密度; （v）活动期间的约束压力比休息期间的约束压力对生理应力参数的影响更为明显。我们的结果表明，大鼠前肢皮质锥体神经元中动态半球依赖性的结构变化与休息和活动时间紧密相关。这些形态变化反映了神经元对外部刺激做出反应的能力，并反映了神经元沟通中的假定变化。

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