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首页> 外文期刊>The European Journal of Neuroscience >Olfactory learning is associated with increased spine density along apical dendrites of pyramidal neurons in the rat piriform cortex.
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Olfactory learning is associated with increased spine density along apical dendrites of pyramidal neurons in the rat piriform cortex.

机译：嗅觉学习与大鼠梨状皮层中锥体神经元的顶端树突沿脊柱密度增加有关。

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摘要

We studied the effect of olfactory learning on the dendritic spine density of pyramidal neurons in the rat piriform (olfactory) cortex. Rats were trained to distinguish between two pairs of odours in an olfactory discrimination task. Three days after training completion, rats were killed and layer II pyramidal neurons identified by Golgi impregnation were examined with a light microscope. Counts of visible spines were performed along the secondary and tertiary branches of both the apical dendrites and the basal dendrites, which are the sites of intracortical synaptic inputs. An estimate of the true spine density was obtained using Feldman and Peters' method (1979, The Journal of Comparative Neurology, 188, 527--542). The estimated true spine density along apical dendrites was higher in neurons from trained rats than those in pseudotrained and naive rats by 15%. As length of spiny dendrites did not change significantly after learning, the learning-related increase in spine density in neurons from trained rats may indicate on an increased number of excitatory synapses interconnecting pyramidal neurons in the piriform cortex, following olfactory learning.
机译：我们研究了嗅觉学习对大鼠梨状（嗅觉）皮层锥体神经元树突棘密度的影响。训练大鼠在嗅觉辨别任务中区分两对气味。训练结束三天后，处死大鼠，并用光学显微镜检查通过高尔基浸渍法鉴定的II层锥体神经元。沿顶部树突和基底树突的次级和第三级分支进行可见脊柱计数，这是皮层内突触输入的位置。使用Feldman和Peters方法（1979，比较神经病学杂志，188，527--542）获得了真实脊柱密度的估计值。在训练有素的大鼠神经元中，估计的沿着根尖树突的真实脊柱密度比在伪训练和幼稚大鼠中的神经元高15％。由于学习后棘突树突的长度没有明显变化，嗅觉学习后，受过训练的大鼠神经元中与学习相关的脊柱密度增加可能表明，在梨状皮层中相互连接的锥体神经元的兴奋性突触数量增加。

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