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首页> 外文期刊>The European Journal of Neuroscience >The psychological and neurochemical mechanisms of drug memory reconsolidation: implications for the treatment of addiction.
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The psychological and neurochemical mechanisms of drug memory reconsolidation: implications for the treatment of addiction.

机译：药物记忆巩固的心理和神经化学机制：对成瘾治疗的影响。

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Memory reconsolidation is the process by which memories, destabilised at retrieval, require restabilisation to persist in the brain. It has been demonstrated that even old, well-established memories require reconsolidation following retrieval; therefore, memory reconsolidation could potentially be exploited to disrupt, or even erase, aberrant memories that underlie psychiatric disorders, thereby providing a novel therapeutic target. Drug addiction is one such disorder; it is both chronic and relapsing, and one prominent risk factor for a relapse episode is the presentation of environmental cues that have previously been associated with drugs of abuse. This 'cue-induced relapse' can be accounted for in psychological terms by reinforcing memories of the pavlovian association between the cue and the drug, which can thus influence behaviour through at least three psychologically and neurobiologically dissociable mechanisms: conditioned reinforcement, conditioned approach and conditioned motivation. As each of these psychological processes could contribute to the resumption of drug-seeking following abstinence, it is important to develop treatments that can reduce drug-seeking re-established via influences on each or all of these pavlovian processes, in order to minimise the risk of a subsequent relapse. Investigation of the memory reconsolidation mechanisms of the memories underlying conditioned reinforcement, conditioned approach and conditioned motivation indicate that they depend upon different neurochemical systems, including the glutamatergic and adrenergic systems within limbic corticostriatal circuitry. We also discuss here the subsequent translation to the clinic of this preclinical work.
机译：记忆重建是记忆恢复过程中不稳定的过程，需要记忆恢复才能在大脑中持续存在。已经证明，即使是古老的，建立良好的记忆也需要在检索后重新整合。因此，记忆重建可能会被利用来破坏甚至消除精神病基础的异常记忆，从而提供一种新的治疗靶点。吸毒成瘾就是其中一种。它既是慢性的又是复发性的，复发发作的一个主要危险因素是以前与滥用药物有关的环境提示的出现。这种“提示诱发的复发”可以通过加强记忆提示和药物之间的帕夫洛夫关联来从心理上解释，从而可以通过至少三种心理和神经生物学上可分离的机制影响行为：有条件的强化，有条件的方法和有条件的动机。由于这些心理过程中的每一个都可能导致禁酒后恢复吸毒，因此重要的是要开发出能够减少对各个或所有这些帕夫洛夫病过程的影响而重新建立的寻求毒品的治疗方法，以便将风险降至最低。随后复发。对有条件的增强，有条件的方法和有条件的动机背后的记忆的记忆巩固机制的研究表明，它们依赖于不同的神经化学系统，包括边缘皮质上皮回路中的谷氨酸能和肾上腺素能系统。我们还在此处讨论此临床前工作的临床后续翻译。

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