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首页> 外文期刊>The European Journal of Neuroscience >Cholinergic and noncholinergic septal neurons modulate strategy selection in spatial learning.
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Cholinergic and noncholinergic septal neurons modulate strategy selection in spatial learning.

机译：胆碱能和非胆碱能的间隔神经元调节空间学习中的策略选择。

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摘要

Rats solving a simple spatial discrimination task in a plus maze initially employ a place-learning strategy, then switch to a motor response strategy. The hippocampus is required for the use of a place-learning strategy in this task. Rats with 192 IgG-saporin lesions of the medial septum/vertical limb of the diagonal band (MS/VDB), that selectively removed cholinergic neurons projecting to the hippocampus, were significantly facilitated in acquisition of the spatial discrimination, and switched from place to response strategies just as control rats did. Rats with ibotenic acid lesions of the MS/VDB, that produced cell loss in the MS/VDB but little damage to cholinergic neurons, were significantly impaired in acquiring the spatial discrimination and did not reliably employ either a place or response strategy at any point in training. This suggests that the MS/VDB modulates hippocampal involvement in place learning, but that cholinergic MS/VDB neurons are neither necessary nor sufficient for using a place strategy to solve a spatial discrimination.
机译：在加号迷宫中解决简单空间歧视任务的老鼠最初会采用位置学习策略，然后转向运动反应策略。在此任务中，使用海马学习策略需要海马。对中隔/垂直对角带（MS / VDB）的192个IgG-saporin损伤的大鼠，选择性地去除了投射到海马的胆碱能神经元，明显促进了空间歧视的获取，并从一个地方转换到另一个地方就像对照组的老鼠一样。患有MS / VDB的ibotenic酸损伤的大鼠在MS / VDB中产生细胞损失，但对胆碱能神经元的损害很小，在获取空间分辨力方面受到了显着损害，并且在任何时候都不能可靠地采用位置或反应策略训练。这表明MS / VDB调节海马参与位置学习，但是胆碱能MS / VDB神经元对于使用位置策略解决空间歧视既不是必需的也不是足够的。

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