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首页> 外文期刊>The European Journal of Neuroscience >Adult microbiota-deficient mice have distinct dendritic morphological changes: differential effects in the amygdala and hippocampus
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Adult microbiota-deficient mice have distinct dendritic morphological changes: differential effects in the amygdala and hippocampus

机译：成年菌群不足的小鼠具有明显的树突形态变化：在杏仁核和海马体中的差异作用

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Increasing evidence implicates the microbiota in the regulation of brain and behaviour. Germ-free mice (GF; microbiota deficient from birth) exhibit altered stress hormone signalling and anxiety-like behaviours as well as deficits in social cognition. Although the mechanisms underlying the ability of the gut microbiota to influence stress responsivity and behaviour remain unknown, many lines of evidence point to the amygdala and hippocampus as likely targets. Thus, the aim of this study was to determine if the volume and dendritic morphology of the amygdala and hippocampus differ in GF versus conventionally colonized (CC) mice. Volumetric estimates revealed significant amygdalar and hippocampal expansion in GF compared to CC mice. We also studied the effect of GF status on the level of single neurons in the basolateral amygdala (BLA) and ventral hippocampus. In the BLA, the aspiny interneurons and pyramidal neurons of GF mice exhibited dendritic hypertrophy. The BLA pyramidal neurons of GF mice had more thin, stubby and mushroom spines. In contrast, the ventral hippocampal pyramidal neurons of GF mice were shorter, less branched and had less stubby and mushroom spines. When compared to controls, dentate granule cells of GF mice were less branched but did not differ in spine density. These findings suggest that the microbiota is required for the normal gross morphology and ultrastructure of the amygdala and hippocampus and that this neural remodelling may contribute to the maladaptive stress responsivity and behavioural profile observed in GF mice.
机译：越来越多的证据表明微生物群参与了大脑和行为的调节。无胚小鼠（GF;出生时缺乏微生物群）表现出改变的应激激素信号传导和焦虑样行为以及社交认知缺陷。尽管肠道菌群影响应激反应性和行为能力的机制尚不清楚，但许多证据表明杏仁核和海马体可能是靶标。因此，本研究的目的是确定GF与常规定居（CC）小鼠相比，杏仁核和海马体的体积和树突形态是否不同。体积估计显示，与CC小鼠相比，GF的杏仁体和海马体明显扩张。我们还研究了GF状态对基底外侧杏仁核（BLA）和腹侧海马中单个神经元水平的影响。在BLA中，GF小鼠的椎间神经元和锥体神经元表现出树突状肥大。 GF小鼠的BLA锥体神经元具有更薄，粗短和蘑菇状的刺。相比之下，GF小鼠的腹侧海马锥体神经元较短，分支较少，且短粗和蘑菇棘较少。与对照组相比，GF小鼠的齿状颗粒细胞分支较少，但脊柱密度没有差异。这些发现表明，微生物体是杏仁核和海马的正常总体形态和超微结构所必需的，并且这种神经重塑可能有助于在GF小鼠中观察到的适应不良应激反应和行为特征。

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