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首页> 外文期刊>The European Journal of Neuroscience >5-HT4 receptors exert a frequency-related facilitatory control on dorsal raphe nucleus 5-HT neuronal activity.
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5-HT4 receptors exert a frequency-related facilitatory control on dorsal raphe nucleus 5-HT neuronal activity.

机译：5-HT 4受体对背ra核5-HT神经元活性施加频率相关的促进性控制。

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摘要

We investigated, using single-unit recordings in chloral hydrate-anaesthetized rats, the role of serotonin 4 (5-HT4) receptors in the control of dorsal raphe nucleus (DRN) 5-HT neuron activity. About one-half (36) of the 76 neurons recorded were affected by either the preferential 5-HT4 agonist cisapride (500 and 1000 micro g/kg, i.v.) or the selective 5-HT4 antagonist, GR 125487 (200- 2000 micro g/kg, i.v.). Responding neurons displayed a significantly higher mean basal firing rate (1.93 +/- 0.1 Hz) than non-responders (1.31 +/- 0.1 Hz). The firing rate of responding 5-HT neurons was enhanced dose-dependently by cisapride (+47 and +94% at 500 and 1000 micro g/kg, respectively), an effect abolished by GR 125487 (500 micro g/kg) and reduced by the 5-HT4 antagonist, SDZ 205557 (500 micro g/kg, i.v). Conversely, GR 125487 induced a dose-dependent inhibition of responders activity, which was almost completely suppressed at the dose of 2000 micro g/kg. In a separate set of experiments, the selective 5-HT4 agonist, prucalopride (500 micro g/kg, i.v), increased the firing activity (+35%) of 5-HT neurons displaying a high basal firing rate; subsequent injection of GR 125487 (500 micro g/kg, i.v.) suppressed this effect. These results indicate that 5-HT4 receptors exert both a tonic and a phasic, positive, frequency-related control on DRN 5-HT neuronal activity. The existence of such a control might open new avenues for therapeutic research in the antidepressant field.
机译：我们使用氯水合物麻醉的大鼠中的单个单元记录调查了血清素4（5-HT4）受体在控制背沟核（DRN）5-HT神经元活性中的作用。记录的76个神经元中约有一半（36）受优先5-HT4激动剂西沙必利（500和1000 micro g / kg，iv）或选择性5-HT4拮抗剂GR 125487（200- 2000 micro g）的影响/ kg，iv）。响应的神经元显示出的平均基础放电率（1.93 +/- 0.1 Hz）明显高于无响应的神经元（1.31 +/- 0.1 Hz）。西沙必利以剂量依赖性的方式提高了响应的5-HT神经元的放电率（分别在500和1000 micro g / kg时分别增加47％和+ 94％），而GR 125487（500 micro g / kg）取消了该作用并降低了由5-HT 4拮抗剂SDZ 205557（500μg/ kg，iv）制备。相反，GR 125487诱导了剂量依赖性的反应活性抑制，在2000 micro g / kg的剂量下几乎完全被抑制。在另一组实验中，选择性5-HT4激动剂普卡洛必利（500 micro g / kg，i.v）增加了5-HT神经元的放电活性（+ 35％），显示出较高的基础放电率;随后注射GR 125487（500 micro g / kg，i.v.）抑制了这种作用。这些结果表明5-HT 4受体对DRN 5-HT神经元活性施加强音和相位的，与频率有关的积极控制。这种控制的存在可能为抗抑郁药领域的治疗研究开辟新的途径。

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